A Month in Neurodegenerative Disease Research (AMiNDR)

Naila brings you 21 articles from January 2024, on non-pharmacological approaches to the prevention and intervention of Alzheimer's disease. You'll be treated to research from computational modeling, to rodent models, to clinical trials, with a particular focus on optimizing and personalizing intervention strategies. This episode also covers some research on the role of caregivers, and several papers consider the socioeconomic and ethnographic context in which these studies take place. Let's...

Join Christy for 12 papers from January 2024 on structural neuroimaging in the diagnosis of Alzheimer's disease. This episode is a bit different from past ones because it's all about the use of machine learning and deep learning. Whether you're an AI researcher or simply curious about the topic, you won't want to miss this episode. Detecting AD (3:42)  Predictions, associations or comparisons (16:48)-------------------------------------------------------------- You can find the bibliography for this episode...

Another series of AMiNDR kicks off with this episode. Anusha takes you through 7 papers published in January 2024 targeting neuroprotection in AD. If you'd like to hear about potential compounds that could reduce neurodegeneration in Alzheimer's disease, this is the episode for you.Testing for neuroprotection in cell lines (2:57)Testing for neuroprotection using in vivo AD models (11:47)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the...

Another special episode to help kick off our return! In what we hope to be a recurring special series, an interview with members in our scholarly community on navigating the multiple facets of life as a scientist. In the first episode, host Kevin Nishimura interviews one of our own Joseph Liang on his personal journey to and through graduate school. Tune in to learn what he has to say about...

In today's episode, Naila provides an overview of 14 articles published in November 2023 on non-pharmacological interventions for AD. You'll hear about cognitive training, music therapy, chair yoga, providing support to caregivers, and a range of neural stimulation techniques. Enjoy! Cognitive and Social Factors (2:26)Lifestyle interventions (13:40)Stimulation Techniques (19:20)-------------------------------------------------------------- You can find the bibliography for this episode here, or by clicking the link below:https://drive.google.com/file/d/1A4HZVCtgh5AwZkd5V2ATZSFAxGJt48q3/view?usp=drive_linkTo access the folder with ALL our bibliographies, follow...

Join us as we cover a set of papers published in November 2023 on treatments targeting cholinergic transmission in Alzheimer's disease. In this episode hosted by Christy, we will go over various topics, from drug discovery using synthesized compounds to drug testing of plant extracts, as well as improving drug delivery through the blood-brain barrier. Enjoy! Papers evaluating synthesized compounds (2:00)  Papers targeting AchE (10:45)-------------------------------------------------------------- You can find the bibliography for this...

As we get back up to speed on our regular episodes, we thought we'd treat you (and ourselves) to something out of the ordinary: a conversation on how visual storytelling can shape how we think - and feel - about Alzheimer's disease. Host Naila Kuhlmann had the pleasure of interviewing Gina Martin, who founded the Bob and Diane Fund to support and promote visual storytelling about Alzheimer's and dementia. Tune...

Hello listeners, it’s been a while since we last released an episode but we are back with another series here at AMiNDR bringing you a synopsis of publications on Alzheimer’s disease (AD) research on various topics that were released in November of 2023. In this episode, Anusha takes you through 11 papers testing potential neuroprotective agents for AD treatment. You’ll hear about naturally and pharmaceutically-derived compounds as well as strategies...

If you’re interested in hearing about the impact of hearing aids on quality of life in AD patients, or how having a stable life partner can slow down the progression of dementia, tune in to this episode on the latest in cognitive and behavioural research in Alzheimer's disease! Judy will cover 9 papers on sleep, depressive symptoms and sensory processing, all published in February 2023. This is one you don't...

In today's episode, Naila provides you with an overview of 10 paper published in February 2023, on non-pharmacological therapies for Alzheimer's disease. You'll learn about a virtual reality intervention targeting anxiety, the signaling pathways underlying the potential benefits of acupuncture, the challenges of implementing new interventions, and what spectral light flicker means. Happy listening!  Sections in this episode:  Psychological Interventions (1:37)  Physical Activity (7:26)  Neuromodulatory Techniques (14:05) -------------------------------------------------------------- You can find the...

This short and sweet episode kicks off the February 2023 series, highlighting studies all the way from worms to humans. Anusha will take you through 9 papers that converge on targeting neuroprotection in Alzheimer's disease. If you're interested in learning about implicated pathways or potential therapeutics, this episode is sure to whet your appetite.  Sections in this episode:  Targeting Specific Neuroprotective Pathways (3:39)  Targeting Neuroprotection Broadly (13.21) -------------------------------------------------------------- You can find the...

Elyn's back with more insight from the field on how blood vessel health impacts brain health. Tune in for a journey through mechanisms underlying increased risk from "vascular risk factors" like hypertension, diabetes, and atrial fibrillation, lots of neuroimaging studies providing clinical insights, and several interesting novel therapeutic avenues. If you weren't already convinced that the vasculature is relevant in the context of AD, you sure will be after this...

This episode covers some papers from January 2023 on treatments focused on repairing the neurotransmitter imbalance in Alzheimer's disease. We hope you enjoy listening as Christy summarizes this exciting research—from the discovery of new therapeutics to the synthesis of drugs. Sections in this episode:Drug Screening (3:37)New Drugs (7:00)Synthesized Drugs (13:35)-------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1BkF6ofShRYL_ggRRFKvNsHvBz4PrLfXr/view?usp=share_linkTo access the...

In today’s episode of AMiNDR, Ellen will tell you all about the functional connectivity of different networks in the brain, and changes to brain structure and volume in Alzheimer’s disease. This includes how these changes in the brain relate to cognitive changes, behavioural symptoms, and other neuropathological markers. There are many fascinating studies to hear about today!  Sections in this episode:  Functional Connectivity (4:26)  Excitation/Inhibition Balance & Neuronal Hyperactivity (17:48)...

Naila covers 11 papers from January 2023, with a focus on a variety of stimulation techniques. You'll get a smattering of new research from humans to mice to flies, and from brain imaging to computer simulations to molecular mechanisms. Enjoy!  Sections in this episode:  Complementary therapies (2:55)  Current and magnetic stimulation (7:25)  Electroacupuncture (14:30)  Other stimulation techniques (22:15) Other (25:52) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this...

We’ve got a whole variety of studies in this January 2023 episode, spanning from sensory processing, to sleep, and even to depressive symptoms. Tune in to learn more about the latest in cognitive and behavioural changes in Alzheimer's disease!  Sections in this episode:  Sensory Processing (2:28)  Sleep (7:30)  Balance (14:14)  Depression (17:00)  Other (20:40) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use...

In this episode, we’ll be covering papers that were released in January 2023 that target neuronal and synaptic protection in Alzheimer’s Disease. If you’re interested in the preclinical testing of novel therapeutics and delivery methods, this is the episode for you!  Sections in this episode:  Novel Therapeutics Targeting Neuroprotection (4:53)  Novel Delivery Methods Targeting Neuroprotection (8:49)  Targeting Synaptic Pathology (16:42)  Targeting BDNF Activation (23:18) -------------------------------------------------------------- To find the numbered bibliography with all...

We are diving in to all things neurotransmitters and synaptic signaling to kick off the January 2023 series. You'll hear about dopamine, noradrenaline, prion proteins, a new 3D cell culture model, and more, in today's episode. Enjoy!  Sections in this episode:  Monoamine Neurotransmitters (3:50)  Glutamate (9:18)  Acetylcholine (15:51)  Synaptic Proteins (17:43)  New 3D Culture Method (21:32) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here,...

Welcome our new host, Anelya, who covers 12 papers on the role of immune system and glia in Alzheimer’s disease. The first half of this episode will focus on potential targets for the treatment of Alzheimer’s disease, followed by the disease-associated inflammatory mechanisms. Part 2 will be released as a bibliography. We hope you find this episode interesting!  Sections in this episode:  Potential Therapeutic Agents (2:28)  Disease-Associated Neuroinflammatory Mechanisms (14:08) -------------------------------------------------------------- To...

Ellen brings you summaries of 8 abstracts from November 2022, all about functional connectivity and imaging in the context of Alzheimer's disease. There are a variety of brain regions covered in today's episode, including cortical regions, subcortical structures, and the hippocampus. Spanning studies in both humans and animals, this episode is sure to have something of interest to you and your research!  Sections in this episode:  Cortical regions (3:39)  Subcortical...

For today's episode, Naila is back to take you through 20 papers on prevention and intervention strategies in Alzheimer's. You'll be treated to the latest on mindfulness and meditation, the default mode network's involvement in Alzheimer's, strategies for assessing and optimizing therapies, stimulation techniques and more. Enjoy!  Sections in this episode:  Innovation assessment (3:08)  Cognitive Training (6:36)  Mindfulness and Movement (13:39)  Diet (26:00)  Sensory Stimulation (30:24)  Neuromodulatory Techniques (39:45) -------------------------------------------------------------- To find...

In this episode, Anusha guides you through 11 papers that were published in November of 2022. These papers study the efficacy of treatments targeting neuroprotection in Alzheimer's Disease models. Tune in if you want to be on the cutting edge of drug discovery and development in the field of AD.  Sections in this episode:  Drug Discovery and Development of Novel Therapeutics (3:49)  Testing Existing Compounds (17:27) -------------------------------------------------------------- To find the numbered bibliography...

Judy is so excited to take you through part 1 of the behavioural and cognitive changes in AD episode (part 2 will be released as a bibliography). This shorter episode features standard motor symptoms like impaired exercise and grip strength, as well as some less studied behavioural changes such as adverse driving in AD. You don’t want to miss this one!  Sections in this episode: Behavioural Changes (3:30) Learning History (13:45) Depressive Symptoms...

Ellen kicks off the November 2022 series with 11 papers about synaptic transmission and neurotransmitters in Alzheimer's disease. Hear about glutamate, acetylcholine, synaptic proteins, and more in this jam-packed episode!  Sections in this episode:  Glutamate and Acetylcholine (4:01)  GABA neurons (10:52)  Neuron Excitability (12:15)  Synaptic Proteins (15:10)  Neuro-Immuno-Endocrine System (21:45) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1dELth-9F_TVyUTuxPmuIVYKM1MgCuIEf/view?usp=share_linkTo access...

Today, we talk all about neuroimaging, with 7 papers that use various imaging modalities in humans, animals, and computational modeling, to study how the brain changes in Alzheimer’s disease. Tune in to learn more!  Sections in this episode:  Hippocampus (3:50)  Hypothalamus (8:15)  Cortical regions (10:29)  Nucleus basalis (15:57)  Pineal gland (18:40) -------------------------------------------------------------- Due to unforeseen circumstances, the bibliography for this episode will be posted soon - please keep checking back. Thank you...

Anusha brings you another episode of AMiNDR featuring literature published in October 2022. In this episode, you'll hear 12 papers that converge on the topic of treatments that target neurotoxicity. This episode is poised to leave you feeling hopeful about the various treatment avenues to be pursued so be sure to tune in!  Sections in this episode:  Targeting Neurotoxicity in vitro (3:53)  Invertebrate models of AD (8:41)  Transgenic AD models...

In today's episode, there's a big focus on sleep in Alzheimer's disease, as well as other clinical and pharmacological studies that dive into the cognitive and behavioural deficits. We even have one paper that looks into character strengths in AD, so definitely join Judy and follow along in this unique episode from our October 2022 series!  Sections in this episode:  Sleep (2:53)  Behavioural changes in rodent models (7:00)  Behavioural changes...

In this episode, Elyn takes you through 13 papers from October 2022 published on vascular contributions to Alzheimer disease. It's quite the journey through mechanistic mouse studies, neuroimaging studies, and a few studies assessing treatments targeting the vasculature, which all paint a pretty convincing picture of the importance of the cerebrovasculature in brain health. Tune in to learn more about the glymphatic system, consequences of amyloid deposition on the vasculature,...

Kick off the new year with Ellen, who tells you all about synaptic transmission in Alzheimer's disease in this episode. You'll hear about 5 papers published in October of 2022 on synaptic transmission, ranging from research on whole brain networks all the way down to individual proteins. -------------------------------------------------------------- The link to the numbered bibliography for this episode will be coming soon.To access the folder with ALL our bibliographies, follow this link (it...

We have one last episode for you to wrap up 2022! In this episode, Naila will guide you through 11 papers published in August 2022, covering a range of way researchers are working on preventing or treating aspects of Alzheimer's disease through non-pharmacological therapies. You'll hear about cognitive training tools, the effects of disrupting circadian rhythms on metabolism and Alzheimer's, and on vagal nerve stimulation for treating neuropsychiatric symptoms related...

In this month's episode of AMiNDR, Cassi recaps papers on APOE published in August 2022. Cassi just defended her dissertation where she studied immunometabolism in the context of APOE. She starts with cells, moves to mice, and finishes with human research studies. -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/11pGVGJGUWfPNAqJ-Jw7cUGyUGb_HRXwy/view?usp=drivesdkTo access the folder with ALL our bibliographies, follow this...

Today, we have papers on behavioural and cognitive changes in Alzheimer’s disease. We’ve got our usual sections such as rodent models and sleep, but we also have some new topics, including cognitive reserve and even a paper on virtual reality. You’re in for a treat!Sections in this episode:  Behavioural Changes (2:28)  Cognitive Changes (11:10)  -------------------------------------------------------------- To access the folder with ALL our bibliographies, follow this link (it will be updated as...

After a bit of a break, Elyn is excited to be back with the latest in the field of vascular contributions to Alzheimer disease. With the current (and constant) controversy in the field about targeting amyloid as a disease-modifying therapy, perhaps it's time we turned to a new target: the vasculature. Tune in for an overview of papers published in August 2022, including lots of nitric oxide signalling, animal model...

To kick off our series on August papers, we will talk all about different ways that synaptic transmission may be affected in Alzheimer's disease, with 6 research papers that use either cell models, animal models, or human patients. Stay tuned!  Sections in this episode:  Cortical signaling in rodent models (3:15)  New AD models (8:32)  Biomarkers of neural dysfunction in humans (9:24)  -------------------------------------------------------------- To find the numbered bibliography with all the papers...

In Part 2 of Cognitive and Behavioural Changes, Naila covers 8 papers on neuropsychiatric, social and cognitive symptoms linked to Alzheimer's disease, and their implications for diagnosis and disease management. You'll learn about the links between AD and depression, the importance of social networks, and machine learning methods for identifying important lifestyle information from clinical notes. Enjoy! Neuropsychiatric Changes (2:11)Cognitive Changes (10:25)Statistics and Machine Learning (17:05)-------------------------------------------------------------- To find the numbered bibliography with...

In this episode, Naila will guide you through 14 papers on potential neuroprotective factors to mitigate the risk of Alzheimer's disease, non-pharmacological interventions that could directly target Alzheimer's pathology, and strategies for symptom management. You'll hear about the role of embodiment in memory, light therapy technologies, the role of diet, and a few molecular pathways underlying the effects of exercise and neuronal stimulation.Sections in this episode:Cognitive and affective training (2:49) Physical...

This is an episode all about targeting synaptic and neuronal heath in Alzheimer's disease. Anusha will cover in silico, in vitro, and in vivo studies of candidate compounds that target neuroprotection and neurogenesis. Be sure to check out this paper to stay up to day on the latest preclinical therapeutics being tested.  Sections in this episode:  In silico and treatment development (3:24)  Targeting Neurogenesis (7:07)  Targeting Neuroprotection (12:00) -------------------------------------------------------------- To find the...

In this episode exploring the effect of allelic variation of APOE, we review abstracts from large human GWAS studies all the way down to new mouse models expressing the human ApoE proteins. There are some particularly interesting abstracts on protection from cognitive decline despite having a risk allele for Alzheimer's disease. These are great studies to open the door for future research in this field!  Sections in this episode:  Human...

Part 1 of our cognitive and behavioural changes category will focus on papers that explore behavioural and sensory processing deficits in AD. Topics range from motor impairments to visual and olfactory processing in both human patients and mouse models of AD. If you're curious about how AD patients process the facial expression of pain, then this is the episode for you!  Sections in this episode:  Behavioural Changes (2:39)  Visual Processing...

Part 1 of our cognitive and behavioural changes category will focus on papers that explore behavioural and sensory processing deficits in AD. Topics range from motor impairments to visual and olfactory processing in both human patients and mouse models of AD. If you're curious about how AD patients process the facial expression of pain, then this is the episode for you!  Sections in this episode:  Behavioural Changes (2:39)  Visual Processing...

Elyn is back to discuss the latest research on vascular contributions to Alzheimer disease! Tune in to hear about proteomic changes with amyloid deposition in the vasculature, new therapeutic avenues, and a more detailed account of the perivascular space. If you're interested in factors beyond amyloid and tau in the Alzheimer disease pathology, this is a great place to start!  Sections in this episode:  Cardiovascular Risk Factors (3:45)  White Matter...

We are kicking off our July 2022 series of AMiNDR with this episode and are so glad you are tuning in. If you’re interested in changes to neuronal function in AD, we’ll be covering the entire spectrum in this episode. Starting big with network changes, we scale all the way down to molecular changes that may underlie AD pathology, so if that’s what you’re interested in, stay tuned!  Sections in...

Today's episode includes 15 papers on non-pharmacological treatments and complementary therapies for AD. Naila will take you through research published in June 2022 on an array of topics including olfactory training, beer, choir participation, light therapy, and transcranial magnetic stimulation. You'll be treated to research on both the human and animal level, with a special focus on targeting neuroinflammation and brain connectivity!  Sections in this episode:  Cognitive Training and Complementary...

We promised you we would be back with more on clinical assessment for Alzheimer’s disease, and here we are to deliver.  Stick around to hear about papers published in June 2022 on validating variations of the Montreal Cognitive Assessment, tracking Activities of Daily living, and digital tools for assessing cognition. Our harvest yielded 7 abstracts, all presented in this episode!  Sections in this episode:  Combinign Multiple Neurocognitive Domains (7.00)  Activities...

Approximately, one in every five people you know, has a copy of the largest genetic risk allele for late-onset Alzheimer's disease called apolipoprotein E4 (APOE). In this episode, Cassi discusses papers from June 2022 about APOE and covers human subjects research, pathology related to E4 risk, and mechanisms.  Sections in this episode:  Human Subjects Research (2:52)  AD Pathology (11:19)  Mechanism (15:12)  Targeting Memory Impairment with Genetic Manipulation (10:51)  Targeting Synaptic...

In this episode, Joseph covers papers published in June 2022 on GWAS studies, transcriptomics, genetic and genomic studies and the like on Alzheimer’s disease. Stay tuned!  Sections in this episode:  Genetic & Disease Overlaps (2:15)  RNA & Transcriptomics (5:10)  Genetic Testing (10:25)  GWAS Studies (15:24)  Specific Genes (21:04)  Extra (28:55) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1diNBktrzfDyUcmjSUiItcdRUNbxEAcNl/view?usp=sharingTo access...

Anusha brings you 12 papers today on the development of treatments that target neuroprotection in Alzheimer's disease. This includes a range of research models, from in silico and drug discovery studies, to rodent models of AD. Enjoy!  Sections in this episode:  In Silico and Drug Discovery Studies (2:27)  Testing Phytochemicals in AD Rodent Models (7:29) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or...

This episode contains a whole range of topics in cognitive and behavioural changes in AD! Tune in as Judy covers a variety of papers published in June 2022, spanning from from sensory processing in mouse models to antidepressants in human patients. There's bound to be something that piques your interest!  Sections in this episode:  Studies Using Mouse Models (2:03)  Sensory Processing (7:15)  Behavioural Changes in AD (13:08)  Cognitive Changes in...

You are here, with us, right now, about to get the updates you eagerly wait for every month in Alzheimer’s disease research. A whole episode dedicated to assessing neurocognitive domains for screening and diagnostics. Learning and memory? Executive function? Perceptual and motor skills? You got it! 7 abstracts published in June 2022, nicely packaged for you in this podcast.  Sections in this episode:  Learning & Memory (7:41)  Executive Function (26:18)...

Ever thought there was more to Alzheimer disease than the plaques and tangles? You've come to the right place. Join Elyn for a guide through the latest research on vascular contributions to Alzheimer disease. June 2022 brought lots of new insight into how vascular hallmarks interact with the classic AD hallmarks to influence cognition, emphasis on vascular pathology in familial Alzheimer disease, and so much more. Tune in for a...

We are kicking off our June 2022 series of episodes with this short and sweet episode. Anusha takes a look at papers published on the subject of changes to synaptic transmission and neuronal excitability in Alzheimer’s disease. If you're interested in bridging the gap between changes to neuronal function and behavioural consequences, this episode is a great place to start!  Sections in this episode:  Changes to neurotransmission and neuronal excitability...

Elyn is back with a short and sweet episode on the latest research on vascular contributions to Alzheimer disease! Tune in for a quick recap of May 2022 research, and a disease perspective a bit more lively than the classic amyloid cascade hypothesis! Clinical Studies (3:53)Preclinical Studies/Methology (12:41)  -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:  https://drive.google.com/file/d/1ykvbecZO_b3jUyCRc-LG6hgj2ORitxKT/view?usp=sharing To access the folder with...

Anusha is excited to guide you through 12 papers published in May of 2022 that all test different treatment options for Alzheimer’s disease, preclinically. She will cover topics like discovery and development of agents that confer neuronal and synaptic protection or target neuronal function directly. This episode is sure to leave you feeling hopeful about future therapeutic directions! Drug Discovery/Development (1:52)Targeting Neuronal Functions (9:19)Targeting Neuroprotection (14:25)  -------------------------------------------------------------- To find the numbered bibliography with...

In this exciting episode, Judy goes over papers published in May 2022 on the latest research involving cognitive, behavioural and clinical changes in AD. Subjects include sensory processing, mouse models, sleep, and many more!   Sensory Processing (1:45)Mouse Models (5:44)Clinical Treatments (8:34)Sleep (12:59)Other (17:29) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:  https://drive.google.com/file/d/1yY6gR2c2e_Big8_Atx_VVb2RqCw6PFZ5/view?usp=sharing To access the folder with ALL our bibliographies, follow...

In this episode, Joseph is back to go over papers published in May 2022 on GWASs, genetics or any other genetics-focused work. Topics include GWAS's, tool development, gene discovery, and social performance-based genetic studies! GWAS and Polygenic Risk Scores (2:20)Cognitive & Social Genetic Studies (8:42)Tool development (11:46)Gene Discovery (14:41)Studies on Amyloid and Tau (16:09) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the...

Welcome welcome! This episode was made for you if you are interested in geriatrics, neurology, or cognitive testing in general, as we will go through the latest publication on clinical assessment of cognitive decline. That’s right, 9 papers published in May 2022 on testing neurocognitive domains for the screening or diagnosis of mild cognitive impairment, Alzheimer’s disease, or dementia in general.   Learning and Memory (7:17)Perceptual and Motor Skills (20:23)Language (22:33)Activities...

AMiNDR is back and excited to bring you more literature on Alzheimer’s Disease. In this episode, we’ve got papers published in May of 2022 on the subject of changes to synaptic transmission and neuronal excitability. Anusha covers subjects like calcium homeostasis, synaptic function, and how to translate findings to humans and human models, so join her if your neurons are excited by the topic!  Sections in this episode: Calcium Homeostasis (2:54) Synaptic Function...

In the final episode of the March 2022 series, Naila takes you through 18 papers on non-pharmacological strategies for preventing or treating Alzheimer's disease. You'll hear the latest from animal studies on exercise, learn about the potential benefits of brown rice, pet ownership and yoga, and be guided through a number of techniques that are being used to modulate brain activity with the hopes of improving cognition or slowing disease...

Welcome back for the second of a 2-part episode on the clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! You will hear about the evaluation of traditional and digital tests for their potential to help us detect AD and distinguish it from MCI. Also on the menu, a few papers on markers of cognitive decline that may help us refine our diagnosis, or even for prognostic...

This is our monthly update on clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! This is the first of a 2-part series on the matter, where we bring together ways to assess cognitive function by looking at one neurocognitive domain, such as learning and memory, language, perceptual-motor skills, and even by looking at activities of daily living. This is perfect for you if you are researching...

Another 12 papers published in March of 2022 awaits you. This episode is all about treatments that target neuroprotection to treat AD. The papers model it by inducing cytotoxicity in the brain, either with molecules like amyloid beta or genetic mutations. Anusha is excited to guide you through promising treatment options, are you excited too?  Sections in this episode:  Stem Cell-Based Therapy (3.01)  Testing compounds in A-Beta AD Models (4.52)...

Ease in to our March 2022 series with 8 papers published on the subject of synaptic transmission in Alzheimer's Disease. Anusha will highlight changes to connectivity and ones caused by APP and Tau proteins so check out this episode to bridge the communication gap in your brain too!  Sections in this episode:  Synaptic Connectivity Changes (1.44)  APP/Tau contribution to Synaptic Dysfunction (7.47) -------------------------------------------------------------- To access the folder with ALL our bibliographies, follow...

In February of 2022, 8 papers were published on the topic of using neuroprotective compounds as treatment for AD. Anusha will guide you through these papers exploring the entire drug discovery pipeline, from discovery to clinical trials.  Sections in this episode:  Drug Discovery (2.01)  Drug Development (4.59)  Clinical Trials (11.58) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1zzsck-2adMbZB8_cYV6B-AyOwd2p_gqt/view?usp=sharingTo access...

February 2022 was full of abstracts using unique therapeutic approaches to target Alzheimer's disease. Cassi presents abstracts on both naturally-occurring and pharmaceutical compounds used to treat various neurodegenerative pathology and symptoms.  Sections in this episode:  Microbiome (1:55)  NF-kappaB signaling pathway (6:12)  Sexual dimorphism (11:34)  Naturally-occurring & pharmaceutical treatments (15:37)  -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1kMrWRHBkkRqSrR9XzuEFbfquLGbb26Qe/view?usp=sharingTo access...

In today's episode, Naila will guide you through 19 papers from February 2022 on the prevalence and incidence of Alzheimer's disease in various study populations, social determinants of health, as well as environmental and lifestyle factors that may influence the risk of dementia. Part 2 will be available as a bibliography, which you can find in our show notes or at www.amindr.com!  Sections in this episode:  Epidemiological Studies (1:56)  Racial/Ethnic...

Welcome back for the continuation of our segment on clinical assessment. You heard about testing specific neurocognitive domains in part 1, and here we’re back to cover abstracts that look at the big picture in assessing cognitive function. We’re presenting 8 abstracts published in February 2022, perfect for you if you’re interested in tracking cognitive decline for the diagnosis of Alzheimer’s disease, Mild Cognitive Impairment, or dementia in general. Sections in...

If you wanted to detect and diagnose Alzheimer’s disease, or assess disease progression, what aspects of cognition would you focus on? In other words, what capabilities would you test to decide if someone is indeed experiencing cognitive decline, had Alzheimer’s disease, or another type of dementia? And what tools could you use? Stay with me to hear about the abstracts dedicated to specific cognitive domains in the clinical assessment of...

This month's episode covers a range of interventions and non-pharmacological treatments that could help prevent or live with AD. Naila will take you through the various mechanisms underlying the impact of different lifestyle interventions, the potential therapeutic effects of exercise, what mushroom consumption and ketogenic diets might have to offer, and plenty of other stimulating topics!  Sections in this episode:  Cognitive and Multidomain Interventions (1:35)  Diet (7:42)  Exercise (12:00)  Neuromodulatory...

Ever wondered how amyloid deposited in cerebral vessels might affect cerebrovascular reactivity? Or how the culture time of iPSC-derived brain microvascular endothelial-like cells changes their phenotype? Well, you've come to the right place. Elyn will take you through all this and more as she emphasizes the importance of cerebrovascular health in the context of Alzheimer disease in this episode covering papers published on PubMed in February 2022.  Sections in this...

In Part 2 of epidemiological studies published in January 2022, we'll focus on the association between cardiovascular health, diabetes and Alzheimer's disease. Naila will guide you through the latest research on how things like blood pressure, body mass index and insulin resistance are related to dementia and to AD pathology.  Sections in this episode:  Cardiovascular Factors (2:35)  BMI (12:25)  Diabetes and Related Conditions (14:49) -------------------------------------------------------------- To find the numbered bibliography with all...

In Part 1 of this 2-part episode on epidemiological studies published in January 2022, Naila will take you through 12 papers on risk and protective factors linked to Alzheimer's disease, ranging from stressful life events, to exposure to greenspace in one's neighborhood, to sleep troubles and testosterone. We cover a lot of ground in this episode, and if you want to cover even more, look out for Part 2 coming...

With her first episode covering papers from 2022, Elyn is back with a lot of new and interesting findings implicating blood-brain barrier dysfunction in Alzheimer disease. Tune in to hear about this and much more in this longer episode covering 15 papers published in January 2022!  Sections in this episode:  Clinical Insights - Vascular Risk Factors (3:46)  Blood-Brain Barrier Dysfunction (9:41)  Amyloid Deposition and Clearance (30:31)  Treatment Avenues (35:22) -------------------------------------------------------------- To find...

Pssst. Did you hear that 14 papers were published in January of 2022 on treatments targeting synaptic and neuronal protection in Alzheimer's disease? Anusha has you covered with papers targeting amyloid-beta-induced cytotoxocity, demyelination, and cognitive dysfunction in animal models.  Sections in this episode:  Treatments using stem cells (2.18)  Protecting against A-beta induced toxicity (4.59)  Protecting against glutamate-induced cytotoxicity (9.20)  Treatments tested in transgenic AD-like mice (12.38)  Treatments tested in AD...

What information do grey and white matter tell us about mild cognitive impairment vs. Alzheimer's disease? Enjoy this episode in which Christy goes over study findings from 12 papers published in January 2022 on the topic of structural brain changes related to AD.  Sections in this episode:  Gray and white matter changes (2.25)  Correlations of structural changes with biomarkers (9.28)  Methods for early detection (15.27)  Software packages for brain volumetry...

Today's episode will take you all the way from the molecular to the human level in 16 papers on non-pharmacological approaches for preventing or treating Alzheimer's disease. Naila will guide you through the latest research on exercise in AD mouse models, nutritional supplements that could decrease the risk of AD, the potential therapeutic effects of repetitive transcranial magnetic stimulation, and more!  Sections in this episode:  Interventions Targeting Cognition (1.50)  Multidomain...

We start off our January 2022 series of AMiNDR with this episode highlighting 9 papers on changes to synaptic transmission in Alzheimer's Disease. In this episode, Anusha will cover topics including changes to GABAergic and glutamatergic transmission and calcium flux in AD-affected neurons. We also have papers looking at age-dependent changes in synaptic function in AD. End neuro-transmission 😉 Sections in this episode:  Changes to GABAergic transmission (2.41)  Changes to calcium...

Discover the latest on risk and protective factors of AD, from the perspective of 18 observational studies published in December 2021. Naila will take you through socioeconomic factors, nutrition, exercise, and various comorbidities related to AD.  Sections in this episode:  Prevalence and Socioeconomic Factors (1:45)  Nutrition (13:11)  Health-Related Factors (18:49) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/15gMFkpU55HqCYCSQMYvaVgVngdY9j8DT/view?usp=sharingTo access...

In this short and sweet episode, Anusha will take you through 7 papers published in December of 2021 on the subject of treatments targeting neuronal and synaptic protection in AD. Exercise your cognitive reserve by tuning into this episode!  Sections in this episode:  Testing Naturally-Derived Compounds (3.35)  Testing Pre-Existing Drugs (10.54) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1Hiyw6KCbidwmpO12pL1unqbHOJYSLbDd/view?usp=sharingTo...

Tickled by tau? Preoccupied with post-translational modifications? Join Kate as she covers the latest papers published in December 2021 on tau protein pathology and targeting tau as a therapeutic strategy in Alzheimer's disease.  Sections in this episode:  Tau Aggregation & Post-Translational Modifications (3:19)  Generalized Tau Pathology & Tau Seeding (7:29)  Treatments Targeting Tau in AD (13:50) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here,...

Tired of the amyloid cascade hypothesis? Think there's more to AD than the plaques and tangles? You've come to the right place! Elyn is back for her final episode covering papers from 2021 on Vascular Contributions to Alzheimer Disease. Tune in to hear about the latest findings relating to cerebrovascular changes in AD, and why they matter.  Sections in this episode:  Insights from Clinical Studies (4:10)  Insights from Animal Models...

In today's episode, Naila will take you through 11 studies from December 2021 on different non-pharmacological methods for treating Alzheimer's disease. You'll hear the latest research on the importance of sleep, how cognitive training might reduce Alzheimer's pathology, and numerous stimulation techniques for improving cognitive function in people with AD. Enjoy!  Sections in this episode: Cognition and Sleep (1.34) Exercise (6.28) Neuromodulatory Techniques (12.16)-------------------------------------------------------------- To find the numbered bibliography with all the papers covered...

This episode of AMiNDR is part 2 of our Clinical Assessment series. Today, you'll hear about new cognitive tests and advancements in existing tools for clinical testing. With every new study on Alzheimer’s disease, we are one step closer to understanding this disease better, diagnosing people faster, and helping people more effectively. Get ready to hear about some of the latest ways that scientists and clinicians are getting us closer...

Can smell, gaze, blinking rate, or handwriting offer a window into what happens inside the Alzheimer’s disease brain? Are there parameters we can add to our batteries for assessing cognitive decline in a clinical setting? Missed opportunities in cognitive assessment? Maybe. This episode is dedicated to all kinds of variables that can help orient ourselves on the Alzheimer’s disease continuum, and perhaps predict the progression from MCI to AD.  Sections...

Could changes to synaptic transmission underlie Alzheimer's disease pathology? Anusha has 8 papers to help you answer that question. These papers assess changes in humans, human models, and animal models and were all published in December of 2021.  Sections in this episode:  Changes in Neuronal Activity in Humans and Human Models (2.50)  Changes in Neurogenesis in APP/PS1 Transgenic AD Mice (10.08)  Changes in Neuronal Activity in APP/PS1 Transgenic AD Mice...

To kick off this series, Ellen tells you about 17 studies published in December 2021 on how different forms of cognition, sensory processing, and psychiatric health can be affected in Alzheimer's disease, as well as papers exploring new treatment options! If you are an Alzheimer's researcher, or are just interested in hearing about the latest progress in this field, you don't want to miss this episode!  Sections in this episode:...

Naila's back with 19 epidemiological and observational studies published in November 2021. It's quite the panoply of topics - you'll hear about marital status, air pollution, metabolic syndrome, medication use and more. We hope you enjoy!  Sections in this episode:  Epidemiological and Environmental (1.44)  Vaccine/Medication Use (15.10)  Psychomotor (22.48)  Metabolic Comorbidities (26.18)  Other Comorbidities (31.11) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or...

Tired of only hearing about tau or a-beta when it comes to AD research? Take a peek behind the scenes with Kate to explore the latest on the proteostasis and autophagy pathways that work to safeguard our cells in 13 papers from November 2021.  Sections in this episode:  Autophagy & Proteostasis Pathology (4:17)  Targeting Proteostasis/Autophagy Machinery (22:21) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click...

17 papers have "Targeting neurotransmission and synaptic dysfunction in AD" written all over it. Figuratively speaking of course. Anusha covers topics like targeting neurotoxicity and calcium flux, or acetylcholine transmission and balance, or even targeting monoamine oxidases to improve AD-like pathology. Better yet, this episode lets you keep up to date as all the papers were published in November of 2021.  Sections in this episode:  Targeting synaptic dysfunction (2.34)  Targeting...

Join Kate for a comprehensive summary of everything tau from papers published in November 2021.  We'll talk post-translational modifications, prion-like seeding pathology, molecular modeling, and even touch on a potential AD therapies targeting this fascinating little microtubule helper. Enjoy! 🙂  Sections in this episode:  Tau Aggregation and Post-Translational Modifications (03:03)  Tau Seeding and General Tau Pathology (12:49)  Novel Therapeutics (22:58) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in...

Interested in a fresh perspective on the etiology of AD? Join Elyn for her monthly tour through the new research on vascular contributions to Alzheimer disease! Whether this is your niche field, or you want to look at the disease through a new lens, this episode is perfect for you. Tune in to hear about endothelial cell biology, a phase 2 clinical trial, and several animal models!  Sections in this...

Welcome all researchers, students, and clinicians who are interested in learning about clinical testing for Alzheimer’s disease! This episode is dedicated to papers published back in November 2021 on new and old assessment methods to help in the diagnosis of Alzheimer’s. This includes testing cognitive processes and performance on activities of daily living, detecting Alzheimer’s, and distinguishing it from other dementias. You will hear about some new cognitive and non-cognitive...

In today's episode, Naila will guide you through 10 papers that were published in November 2021 on preventing and treating Alzheimer's disease. You'll hear about snoring, caffeine consumption, the mechanisms underlying exercise, and a bunch of neuromodulatory techniques that could treat certain aspects of AD. Hopefully you'll find this latest research to be stimulating!  Sections in this episode:  Modifiable Risk Factors (2:02)  Neuromodulatory Techniques (8:55) -------------------------------------------------------------- To find the numbered bibliography with...

You have just entered the magical world of Alzheimer’s literature. You are about to experience 8 papers that do their best to better understand the changes in synaptic transmission in Alzheimer’s disease. Where did we find such curious abstracts you ask? It just so happens that these were all papers published in November of 2021. Ready to go? Close your eyes and let Anusha be your guide through this journey...

To kick off the November 2021 series, Ellen brings you 11 papers published this past November on the topic of Alzheimer's disease and dementia. Tune in to hear about research on chronic stress, sleep quality, and an active compound from the cannabis plant that could be used to treat AD symptoms! That's just a taste of what you'll hear about in this episode that covers a diverse array of research...

In this special episode of AMiNDR, where we sit down with Jenn Kim and Lucy Aceves, two of the creators of the graduate student-run Neuropsyched Magazine! We talk all things graduate school and academia --  from useful tips for choosing a PI, our experiences of grad school during the pandemic, financial barriers we have faced, and establishing boundaries. We also tell you about Neuropsyched magazine, and what working in science...

Naila is back for part 2, to take you through epidemiological studies on lifestyle factors and comorbidities related to Alzheimer's disease. In today's episode, you'll learn about dietary factors, the association between hair loss and AD, and even a little about Covid-19 (sorry!). Lots to learn in just 13 papers!  Sections in this episode:  Lifestyle factors (1:39)  Nutrition (7:08)  Physical and Psychiatric Comorbities (13:30) -------------------------------------------------------------- You can find the numbered bibliography for...

In Part 1 of our episode on epidemiological studies from October 2021, Naila will cover 11 papers on demographic and socioeconomic factors related to dementia and Alzheimer's disease. You'll hear a lot on subjective cognitive decline, education and occupation. Enjoy, and be sure to check out Part 2!  Sections in this episode:  Prevalence and Demographics (1:33)  Education (7:51)  Socioeconomic status and occupation (14:13)  Other (23:38) -------------------------------------------------------------- You can find the numbered bibliography...

Thinking about thinking? Changes to synaptic transmission contribute to Alzheimer's disease pathology. Hear all about 10 papers published in October of 2021 exploring synaptic dysfunction in AD from Anusha who hosts this episode.  Sections in this episode:  Synaptic dysfunction in rodent AD models (2.58)  Synaptic dysfunction in other AD models & human studies (16.41) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below: https://drive.google.com/file/d/1LYhcoVeGPq5QEWzCqqDCvJsOgMdo3jKt/view?usp=sharingTo access...

Elyn is back with your monthly update on vascular contributions to Alzheimer disease! This month she covers 8 papers that primarily focus on the blood-brain barrier, and white matter hyperintensities that reflect cerebrovascular abnormalities. Tune in for some exciting new findings in the field and more data emphasizing the importance of vascular health in dementia.  Sections in this episode:  White Matter Hyperintensities (4:13)  Blood-Brain Barrier (13:57)  Cerebral Amyloid Angiopathy (20:02) -------------------------------------------------------------- You...

New year, new papers! Join Kate for your monthly update on all things proteostasis and autophagy as they relate to both AD pathology and potential new therapeutic interventions. In today's papers, we'll journey through the endolysosomal system, say "Hi" to some new chaperone families, and even discuss the interplay between AD and other distinct neurodegenerative diseases. Enjoy!  Sections in this episode:  Autophagy & Proteostasis Pathology (4:42)  Targeting Proteostasis/Autophagy Machinery (28:48) -------------------------------------------------------------- You...

Welcome to our first episode of 2022! Marcia will bring you 13 genetics papers from October 2021. We will talk about all kinds of topics - right from AD-associated loci to polygenetic risk stratification, all of which can contribute to planning effective treatment strategies. Tune in!  Sections in this episode:  Transcriptomics/Gene Expression Changes (2:33)  Genetic Variants (6:16)  Genetic Risk (13:14)  MicroRNA (20:10)  Other Topics (22:52) -------------------------------------------------------------- You can find the numbered bibliography...

Join Marcia for Part 1 of this genetics episode covering a total of 13 papers. In this one, she talks about papers from October 2021, related to transcriptomics, especially genes that are differentially expressed In Alzheimer’s disease, and some studies with vertebrate and invertebrate AD model organisms and risk loci. Tune in to learn more! Sections in this episode:  Transcriptomics/Gene expression changes (2:45)Model organisms (17:21)  Risk alleles/variants (22:16)  Methods (27:09)  -------------------------------------------------------------- You...

Hello there! Just in time for the holiday season we've got quite the deal lined up for you. Two episodes for the length of one! Anusha will be guiding you through the literature of October 2021 that focuses on targeting neuronal function and neurotransmission as an Alzheimer's disease treatment. If you want to find out the progress we've been making as a field towards finding better treatments, this is the...

We've got a short and sweet episode for you today, with 7 papers from October 2021 on the intervention and prevention of AD. Tune in to hear Naila ramble on about pet therapy, update you on diet and exercise research in animal models, and provide a stimulating overview of neuromodulatory techniques.  Sections in this episode:  Complimentary Therapies (2:55)  Lifestyle Interventions (9:30)  Stimulation Techniques (13:28) -------------------------------------------------------------- You can find the numbered bibliography for...

We have 14 papers in this episode using structural magnetic resonance imaging (sMRI) in the diagnosis or prognosis of Alzheimer's Disease. Join Christy as she walks you through some deep learning based frameworks and other automated models, as well as new findings with grey matter atrophy.  Sections in this episode:  Deep Learning (2:38)  Automated Algorithms & Models (8:24)  Grey Matter (17:20)  Others - White matter and the Retina (25:00) -------------------------------------------------------------- You can...

Kate lets you know what's going on in the world of tau protein research in this episode of AMiNDR! Tune in to hear all about tau seeding, tau pathology, and potential therapeutic interventions for Alzheimer's Disease that target this protein. Enjoy!  Sections in this episode:  Tau seeding-related pathology (3:40)  Targeting tau for therapeutic interventions in AD (14:35) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the...

To kick off our series on papers published in October 2021, we'll look at 7 papers that rely on Positron Emission Tomography (or PET) imaging to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this...

Feeling like we're beating a dead horse with the amyloid cascade hypothesis? Think there's an X-factor to Alzheimer disease that is tied to both the clinical symptoms and the plaques? Could be the vasculature! Elyn is back to take you through the 12 papers published on vascular contributions to Alzheimer disease, and hopefully get you excited about this blossoming line of research and the new treatment avenues that come with...

Were you looking to learn about clinical testing for Alzheimer’s disease? This is Part 2 of our monthly episode on cognitive and clinical markers for diagnostic and prognostic purposes. Come learn about tests for psychomotor, visuospatial and motor abilities, as well as genetic screens for detecting AD. You will also learn about new cognitive tests for for distinguishing AD from other dementias, or detecting MCI and AD, something we are...

You may have come across a variety of exams used to test cognitive function and assess cognitive decline, such as the Addenbrooke's Cognitive Examination, the mini mental state exam, the clock drawing test, and many more. So how are we doing with these? And how well do they apply in special populations such as people with intellectual disability? Is there room for racial bias in how they are administered? And...

This episode is short and sweet, covering 7 papers on cognitive training, exercise and stimulation techniques. Naila will guide you through the latest in animal models and underlying mechanisms for these potential non-pharmacological interventions.  Sections in this episode:Cognitive Training (2:06) Exercise (4:23) Stimulation Techniques (11:38)-------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1PjokO3cFgLOjtRyi9yjQlckHRNKMtiEM/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follow this...

Ellen tells you about research on topics such as cognitive reserve, reinforcement learning, psychiatric conditions, sleep issues, speech,  and more in this jam-packed episode on cognitive and behavioural changes in Alzheimer's Disease. Sections in this episode: General Cognition (3:32) Reinforcement Learning (14:09) Speech and Language (16:33) Visuospatial and Motor Control (25:06) Psychiatric Changes (28:15) Sleep and Circadian Rhythms (35:16) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1PjokO3cFgLOjtRyi9yjQlckHRNKMtiEM/view?usp=sharingTo access the folder...

Back for part 2, Naila takes you through 15 papers pertaining to health conditions associated with AD and dementia. You'll hear about infections, cardiovascular and metabolic risk factors, and a few miscellaneous diseases.  Sections in this episode:  Epidemiology / Multiple Factors (1:00)  Immune Conditions (8:00)  Metabolic and Cardiovascular (15:00)  Neurological Comorbidities (24:50) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1Pgl18mXwvDG2xZK9fijICMtfEhI7BXUG/view?usp=sharingTo access the folder...

In today's episode, Naila takes you through 10 papers on risk factors associated with Mild Cognitive Impairment, Alzheimer's and dementia. You'll hear a little on lifestyle factors, air and noise pollutants, and hormones. Stay tuned for Part 2!  Sections in this episode:  Lifestyle & Environmental Factors (2:09)  Hormones (15:13) -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1BUfTeMbAC0HzYcXRieJSQdsoNKS9r2J7/view?usp=sharingTo access the folder with all the...

Join Glory to learn about the newest genetic variants and mechanisms that have been linked to Alzheimer's disease. In this episode, we'll cover protective and pathogenic AD variants in genes, potential genetic biomarkers for AD, and differential gene expression that can be observed in individuals with AD. With 19 papers from September 2021, you'll hear about some genes that will be worth following up on in the near future to...

Tune into this month's episode on the latest research on autophagy and proteostasis in Alzheimer's Disease. This includes papers on how autophagy and protein homeostasis are dysfunctional in this disease, and potential treatments that target these cellular pathways. Enjoy!  Sections in this episode:  Proteostatic and autophagic dysregulation (4:33)  RNA splicing, binding, and signaling (10:32)  Glycans, glycoproteins, and fatty acids (19:29)  Amyloid precursor protein (24:16)  Targeting Proteostasis/Autophagy Machinery (26:55) -------------------------------------------------------------- You can find...

Let’s take a trip with Vee through the latest literature to the mitochondria and learn about oxidative stress, metabolism and related therapeutics in Alzheimer’s disease pathology. A jam packed session from vitamins to energy homeostasis to metal chelators- this episode has it all! We have 10 publications from September 2021, which will surely “power” your interest. Tune in and get ready to charge up on the exciting research!  Sections in...

Let's take a closer look at 18 papers published in September 2021 that rely on positron emission tomography (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into this episode.  Sections in this episode:...

Tired of untangling the tricky world of tau literature all on your own? Interested in the mechanisms of tau pathology, therapeutic advancements targeting tau, or both? Join Kate for another exciting episode covering 20 new papers published in September 2021. We’ll explore tau aggregation, regulation, and treatment development through a wide variety of model systems, from molecular dynamics all the way to human subjects - so, tune in to learn...

18 papers published in September of 2021 await you. What do they all have in common? They explore treatments for Alzheimer's disease that all target neurotransmission. If you're interested in restoring acetylcholine balance or other treatments that also improve cognitive function in Alzheimer's disease, tune in to hear Anusha take you through the literature.  Sections in this episode:  Discovery and synthesis of novel cholinesterase inhibitors (3.17)  Tacrine-based cholinesterase inhibitors (11.26)...

Are you interested in neuronal hyperexcitability, impairments in synaptic plasticity, and interactions between amyloid plaques and synaptic proteins in Alzheimer's disease pathology? You've come to the right podcast! In this episode, Glory will guide you through 11 publications from September 2021 on the latest research about the mechanisms of synaptic transmission and plasticity that contribute to the Alzheimer's disease. Hit that play button to hear all of the exciting new...

The first episode of our September 2021 series gets us acclimated with papers that target neuronal and synaptic function in preclinical studies of Azheimer's disease. Join Anusha and she walks you through papers that explore topics like rescuing amyloid beta-induced toxicity, restoring neuronal morphology, and using animal models of Alzheimer's disease to target neuronal function. Sections in this episode:  Targeting A-Beta-Induced Toxicity (2.21)  Restoring Neuronal Morphology and Promoting Neurogenesis (7.26)  Restoring...

This is part 2 of our episode on clinical markers for Alzheimer’s disease, where we cover papers published in August 2021. How does a translation of your favourite cognitive test perform in a Chinese, Slovenian or Persian population? What measures are we currently ignoring but should be include in our battery of tests to detect Alzheimer’s disease or mild cognitive impairment? There is new stuff on this regularly, so come...

Do you want to brush up on your knowledge of MoCA, ADAS-Cog, the MMSE and other cognitive tests? Join Sarah to hear about the 7 papers published in August 2021 where we’re evaluating existing tests for their specificity and sensitivity in detecting Alzheimer's disease and mild cognitive impairment.  -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1w5W2UPrmR7vRgFtjsWj4KBMXh3qhFHoN/view?usp=sharingTo access the folder with all the bibliographies...

In today's episode of AMiNDR, we’ll be talking about the latest work on cognitive and behavioural changes in Alzheimer's Disease, including papers on executive functioning, depression, social impairments, motor coordination, and more. Join Ellen as she guides you through 18 papers on the mechanisms behind cognition and other neuropsychological symptoms in AD!  Sections in this episode:  Cognitive Profiles (4:07)  Executive Functions (13:06)  Exercise & Cognition (18:12)  Psychiatric & Social Symptoms...

Are you familiar with protein aggregation in Alzheimer's disease, but want to learn more about the mechanisms cells use to fight back against these stubborn species? Join Kate in exploring the landscape of cellular processes governing proteostasis and autophagy as they relate to AD. In this short-but-sweet episode, we'll cover a total of 7 papers focused on AD pathology involving autophagy and/or proteostasis dysfunction, as well as treatments targeting these...

Buckle down and get ready for a lengthy episode on the most recently discovered familial mutations and variants related to Alzheimer's disease. With Glory as your host, we'll take a look at different variants in genes that may make you more or less susceptible to developing AD. A large chunk of the episode will cover single nucleotide polymorphisms that have been found in various populations and correlate with neurodegenerative disease....

Join Marcia as she explores the what’s, how’s, and why’s of all things oxidative stress, mitochondrial dysfunction and metabolism in AD.  With this month’s - August 2021- papers, you’ll hear about the latest related cell and animal model studies, AD-adjunct diabetes, and even about potential therapeutics! So sit back and enjoy!  Sections in this episode:  Metabolism (2.40)  Oxidative Stress (11.02)  Mitochondrial Dysfunction (22.25)  -------------------------------------------------------------- You can find the numbered bibliography for this...

Make yourself comfortable, because we cover a lot of ground in today's episode. Naila will guide you through 24 papers from August 2021, all pertaining to epidemiological studies on the risk and protective factors related to AD. You'll hear about some basic epidemiology, environmental and socioeconomic risk factors, lifestyle factors, and health conditions related to AD. Sections in this episode: Epidemiology & Social Factors (1.52) Diet (16.53) Sleep (24.19) Comorbidities (28.00) -------------------------------------------------------------- You can find the numbered...

Tired of the age-old amyloid cascade hypothesis? Think there's more to Alzheimer disease than amyloid and tau? Join Elyn in unpacking the latest literature on vascular contributions to Alzheimer disease from papers published in August 2021. This is another relatively short one, packed with exciting new insights!  Sections in this episode:  Cardiovasular Risk Factors (4:30)  White Matter Hyperintensities and Cerebral Small Vessel Disease (8:28)  Vascular Changes: Perivascular Spaces, Pericyte Coverage,...

Want to know more about about how the brain's different neurotransmitter systems aren't functioning properly in Alzheimer's disease and how hippocampal synaptic plasticity impairment contributes to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity that contribute to the Alzheimer's disease pathology. With this month's new papers, August 2021 gives us 12 publications that try to answer all of your questions...

“Changes to the expression of genes may influence the delicate balance between disease and health”. If you want to learn about how that is relevant to Alzheimer’s disease, you’ve come to the right place! Join Marcia for this short episode, as she discusses how & why gene expression, its epigenetic regulation and integrative studies are important in Alzheimer’s disease! Sections in this episode: Transcriptome (2:35) Multiomics (8:19) Epigenetics (12:03)  -------------------------------------------------------------- You can find the numbered bibliography...

Today, Kate will be focusing on everything tau-related in 12 papers published in August 2021, including aspects of tau pathology and exploring potential therapeutics targeting tau in Alzheimer’s disease! Sections in this episode:Tau Aggregation & Post-Translational Modifications (PTMs) (3.16)Tau Pathology & Seeding (13.30)Targeting Tau for Treatment (20.10)-------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1IIilzUhWAF_WuBM4trkcW12daiB52sT2/view?usp=sharingTo access the folder with all the bibliographies for 2021...

This is an episode that explores the creation and testing of drugs that aim to restore neurotransmitter balance in Alzheimer's disease. It covers 14 papers that were all published in August of 2021, and Anusha will guide you through papers on targets including cholinesterases, serotonin, and glutamate receptors. Hit that play button if you'd like to hear more.  Sections in this episode:  Targeting acetylcholine with novel compounds (2.29)  Other targets...

In this short and sweet episode, Naila covers 7 new papers on prevention and intervention of Alzheimer's disease. You'll hear about upcoming clinical trials of behavioural and cognitive interventions, a little bit about the mechanisms underlying the therapeutic effects of exercise, and about non-invasive stimulation techniques for treating AD.   Sections in this episode:  Cognitive / Physical Training (1:57)  Neuromodulatory Techniques (9:27)  -------------------------------------------------------------- You can find the numbered bibliography for this episode by...

Another month passed means another month of literature for AMiNDR to bring to you! This time, Anusha will be highlighting papers from August of 2021 that are about treatments targeting neuroprotection and synaptic activity in Alzheimer's disease. Beginning with computation and cuvettes and ending with clinical trials, we have 15 papers for your perusal so check out this episode if this topic tickles your fancy.  Sections in this episode:  Drug...

Today's episode covers 18 papers on prevention and intervention strategies for Alzheimer's disease and dementia. Naila will take you through clinical trials and animal studies on cognitive training programs, complementary therapies, diet, exercise, and neuromodulatory techniques. There's a lot of unique papers in this one, so we hope you enjoy!  Sections in this episode:  Cognitive Training (2:52)  Complementary Therapies (6:08)  Diet (15:30) ; Exercise (19:56)  Neuromodulatory Techniques (28:51)  -------------------------------------------------------------- You can find...

Journey through the entire spectrum of drug development as Anusha guides you through 19 papers that were published in July of 2021. We span research that begins with drug discovery all the way to the end goal: Phase II clinical trials. If you're interested in targeting levels of acetylcholine and monoamines, you're really going to like this episode!  Sections in this episode:  Synthesis and Discovery of Cholinesterase Inhibitors (2.47)  Drug...

In this episode, Ellen tells you about 9 papers that have developed new ways to screen for dementia. Some of these are old, tried-and-true cognitive screening tools that are given a new twist, others are brand new technology that bring cognitive testing to the modern age. You’re sure to find something you enjoy in this episode if you do neurodegenerative disease research, or even if you don’t!  Sections in this...

In the first part of this 2-parter episode, Ellen covers studies that compare and contrast different cognitive tests, or analysis techniques, for diagnosing AD at early stages, or predicting the conversion of pre-dementia stages to Alzheimer’s Disease. There are also some studies that compare cognitive abilities between different types of dementia. You'll hear about memory, spatial awareness, social cognition, and more!  Sections in this episode:  Cognitive decline & memory (3:32)...

Kate brings you the latest research on tau pathology in Alzheimer's Disease. This includes post-translational modifications, tau aggregation and seeding, and targeting tau in treatment development. Enjoy!   Sections in this episode:  Tau Pathology (4:35)  Post-translational modifications (4:56)  Tau aggregation and seeding behaviour (16:30)  Targeting Tau for Treatment Development (21:09)  -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1xBMvUdqdBPnGQDnv9qBk9icbKBNEbdXZ/view?usp=sharingTo access the folder with all the...

Interested in how the 700km of blood vessels in the brain are linked to Alzheimer disease? Turns out there are a lot of common threads! In this episode, Elyn covers a series of clinical and preclinical papers exploring vascular risk factors, genetic risk factors like APOE, and signs of vascular damage that are linked to Alzheimer disease. Tune in for an exciting perspective on Alzheimer disease, outside of the classic...

In this shorter episode, Judy covers studies on structural and functional connectivity changes in AD, as well as new methods of integrating multimodal neuroimaging data. All 9 papers were published in July 2021 and focus on improving AD diagnosis using deep learning, specific fMRI measures and more - be sure to check it out!  Sections in this episode:  fMRI (2:11)  Default Mode Network (8:16)  Other (10:10)  -------------------------------------------------------------- You can find the numbered...

Animal and cell models of Alzheimer's Disease are featured in this episode that covers potential therapeutics that target neuroprotection. We have 5 papers that focus broadly on the subject and 10 more that delve into mechanisms of action of these compounds so join Anusha as she highlights July of 2021's publications on the topic!   Sections in this episode:  Treatments targeting neuroprotection (1.03)  Mechanism of treatments targeting neuroprotection (11.14)  -------------------------------------------------------------- You can find...

Visual reaction time, japanese orange scent, language, psychosis, and insomnia are just some of the topics you’ll hear about today in this episode. Have we piqued your interest? Today Ellen tells you about the latest papers on the mechanisms of, and treatments for, cognitive and behavioural changes in Alzheimer's Disease. Enjoy the show!  Sections in this episode:  Sensory processing & function (3:31)  Speech (9:16)  Learning & memory (11:17)  Psychiatric changes...

Glory's back for another episode with all the latest updates on research about how disruptions in certain mechanisms of synaptic transmission and plasticity contribute to Alzheimer's disease. We'll be featuring 14 papers published in July 2021 that cover all things synaptic in AD, including ion channel function and LTP! Join us for an episode that's sure to stimulate your own synapses!  Sections in this episode:  Neurotransmitters (3:00)  Neuronal excitability/activity (11:29)...

“Omics”, “differential expression” and “biomarker discovery” – Are these phrases you commonly use in your research? Or have you come across them and wondered what they meant in the context of AD? If you're nodding your head at either of those, this episode is just for you. Join Marcia as she brings you the latest research published in July 2021 on ‘RNA, Transcription and translation in AD’! Sections in this episode:...

Curious about oxidative stress, default mode network markers and EEG patterns associated with Alzheimer's disease? Join us for an exciting episode on metabolic changes, hemodynamics and EEG featuring papers published in July 2021! Studies include conventional and newer methods of improving AD diagnosis, such as recording electrical activity from the outer ear using electrovestibulography or tracking brain metabolite changes in real time with functional magnetic resonance spectroscopy. Come hear about...

In this episode, Anusha will guide you through 20 papers that tackle acetylcholine and glutamate imbalances in Alzheimer's Disease. These papers were published in June of 2021 and address topics like inhibiting cholinesterases and NMDA receptors. We hope this information transmits to your neurons!  Sections in this episode:  Novel Anti-Cholinesterase Drugs (2.39)  Existing Anti-Cholinesterase Drugs (16.28)  Targeting Glutamate (26.17) --------------------------------------------------------------  To access the folder with all the bibliographies for 2021 so...

In this episode, Maria will be going over 17 papers published in June 2021 on Clinical Indicators of Alzheimer's diseaes and mild cognitive impairment. Topics covered will include the use of technology to assess cognition, semantic memory, cognitive tests, behavioural tests, oculomotor tests, and language adaptations. If you're interested in new ways of detecting AD, make sure you tune in! Sections in this episode:Technology for AD and MCI (2:08) Semantic Memory(8:11) Test for...

Naila has 23 papers for you today, that will provide you with an overview of epidemiological research published in June 2021. You'll hear about the incidence and prevalence of AD in specific populations, sociodemographic and health conditions that increase the risk of dementia and AD, and about a few potentially neuroprotective factors as well. Enjoy!   Sections in this episode:  Prevalence, incidence, multiple factors (2:08)  Cardiovascular (20:33)  Other health conditions (25:30)...

Here, we'll be taking a closer look at 14 papers published in June 2021 that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune it.   Sections in this...

Interested in brain connectivity changes specific to Alzheimer's disease? Come join us as Judy presents 13 papers featuring fMRI, machine learning and other brain mapping techniques that explore functional connectivity in AD. You're sure to learn something new!  Sections in this episode:  fMRI (01:32)  Machine Learning (12:10)  Other (14:36)  -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1qQcxhvhiOUvDSfqcLh4FbI43oFEEelrm/view?usp=sharingTo access the folder with all the...

With a shorter epsiode than usual this month, Elyn is back with an update on vascular contributions to Alzheimer disease and potential treatment avenues targeting the vasculature. Tune in for a summary of 8 papers spanning clinical studies that unpack neuroimaging hallmarks of vascular changes in AD, all the way to mechanistic studies focused on understanding blood-brain barrier dysfunction in Alzheimer disease, and a bonus inclusion of a fluid biomarkers...

Only 14 papers published on APP processing and Amyloid-beta aggregation in the month of June, what’s going on? Well, it is still our pleasure to give you brief summaries on the matter, so if you research Alzheimer’s disease, you do want to tune in for your monthly update on secretase activity, seeding of misfolding, metal ion content of aggregates, and amyloid-beta toxicity.  Sections in this episode:  APP Processing & Secretases...

In this short and sweet episode, Naila covers 12 papers from June 2021 regarding non-pharmacological strategies to prevent or intervene in dementia progression. You'll hear about a few exercise programs, some creative ways to improve quality of life for people with dementia and caregivers, and a range of neuromodulatory (stimulation) techniques.  Sections in this episode:  Exercise (1:37)  Multidomain / Other (7:05)  Neuromodulatory Techniques (15:20)   -------------------------------------------------------------- You can find the numbered bibliography...

Join our host Anusha as she takes you through papers published in June of 2021 that target neuroprotection as a potential treatment avenue for Alzheimer's disease. Half these papers use amyloid-beta induced models of Alzheimer's disease so be sure to check it out if neuroprotection is up your alley.  Sections in this episode:  Treatments targeting neuroprotection in amyloid-beta induced AD models (2.03)  Neuroprotection in other AD models (12.51)  --------------------------------------------------------------  You can...

In this shorter episode, Judy goes over papers published in June 2021 that focus on diagnostic tools of Alzheimer's disease. Topics include metabolic changes, hemodynamics and EEG biomarkers. Listen in to find out more!  Sections in this episode:  Metabolic changes in AD (1:20)  Hemodynamics (9:30)  EEG (13:30)  -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1lzkStThvq02V_tpeuqBDfmZuLlhg6RwQ/view?usp=sharingTo access the folder with all the bibliographies for...

Curious about how neuronal hyperactivity and hippocampal synaptic plasticity impairment contribute to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity affected in Alzheimer's disease. This month, June 2021, delivers 17 new papers that will fill you in on all things synaptic in AD! Give it a listen to find out more and stimulate your own synapses!   Sections in this episode:...

We know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 papers from June 2021.  Sections...

Ellen kicks off this series by telling you about the latest research from June 2021 on topics like cognition, memory, reading, gait, speech, depression, sleep, and even more. Learn how these symptoms may manifest in Alzheimer's disease patients, and the underlying mechanisms that contribute to them. If you're interested in behaviour and cognition in humans or in animals, this episode is for you! Sections in this episode:  Cognition & Attention (3:32)...

From standard clinical testing to motor assessments such as gait performance and handwriting ability, Judy will cover 10 papers on various types of markers in Alzheimer's Disease. Tune in for our final May 2021 episode and learn something new about the different techniques used in AD diagnosis! Sections in this episode: Clinical Testing (1:58) Motor Assessments (7:39) Semantic Dementia (11:28) Sleep (14:03)  -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the...

In this episode, Maria goes over 22 papers from May 2021 on various cognitive tests for Alzheimer's disease and mild cognitive impairment. Paper topics include tests of general cognition, visual, verbal and auditory tests, dementia subtypes, machine learning, and language and culturally adapted tests.   Sections in this episode:  General cognition (2:00) Visual, verbal, and auditory testing (13:50) Other dementia subtypes (18:43) Machine learning (25.08)Language and cultural adaptations (29.32)-------------------------------------------------------------- To access the folder with all...

In the second part of our episodes on amyloid-beta, we focus on the ways abeta contributes to AD pathology. This ranges from its effects on the hippocampus and memory, to more mechanistic studies on ion homeostasis, lipid membrane integrity, and prion-like seeding, without forgetting our friend tau!  Tune in for an episode as eventful as an episode of Game of Thrones where amyloid-beta wages a war on the good people...

This episode of AMiNDR highlights literature published in May of 2021 that target neurotransmitter balance in Alzheimer's Disease. Greatest hits include cholinesterase inhibition, targeting glutamate excitotoxicity, and there's even a bonus paper on adrenergic transmission. Get excited! But maintain homeostasis.   Sections in this episode:  Targeting cholinesterases and oxidative stress (1.56)  Targeting glutamate and excitotoxicity (22.33)  Targeting Adrenergic Receptor (26.58)  -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so...

Wow - May 2021 is a productive month for AD genetics research! Tune in and Joseph will take you through 19 papers on studies to do with new variants, novel genetic insights, or studies on familial AD genetics.   Sections in this episode:  Methods for Gene and Pathway Discovery (1:46)  GWAS, Transcriptome, Exome Sequencing (5:47)  Miscellaneous (12:55)  Familial AD (17:11)  -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here,...

In this episode, Courtney takes you through the papers from May of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, metabolism, peripheral inflammation and so much more! Tune in for this exciting episode! Sections in this episode:  Microglia (02:07)  Astrocytes (10:42)  TREM2 (13:34)  Metabolism (18:08)  Periphery (24:53) -------------------------------------------------------------- You can find the numbered bibliography...

In part 2 of this set of episodes, Ellen dives into papers on psychiatric changes and sleep disturbances in the context of AD. This includes research looking at depression, anxiety, agitation, circadian rhythm, and more in AD patients, animal models, and even clinical trials! There's sure to be something for everyone in this diverse set of papers, enjoy! Sections in this episode:  Depression (2:27)  Anxiety (5:26)  Stress & PTSD (9:55)  Agitation...

Hello hello to fellow baptists, tauists and all protein aggregation enthusiasts! Sarah brings you 15 papers from the month of May on Amyloid-beta aggregation! This is the first part of a 2 episode series on understanding the role amyoid-beta plays in Alzheimer’s disease pathology, and you will hear about APP processing and localization, then amyloid-beta generation and aggregation. We will also throw a teaser on Amyloid-beta detection with a focus...

In this episode, we’ll take a closer look at 13 papers published in May 2021, that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer’s disease! Make sure to take a listen if you’re interested in learning more about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities. Sections...

In part one of this 2-parter, Ellen will tell you all about the latest studies on cognition and motor deficits in AD. This includes mechanistic studies, as well as studies looking at potential treatment avenues for these symptoms. We hope you enjoy, and stay tuned for part 2 coming out soon! Sections in this episode:  Cognition in AD patients (4:09)  Cognition in animal models (9:38)  Motor impairments (19:00) ------------------------------------------------------------- PLEASE  FILL OUR SURVEY ...

From working memory tasks to mouse models, and even to lexical semantics, Judy goes over a wide range of papers that study AD diagnosis using a variety of neuroimaging techniques. Check out this episode if you're interested in hearing about changes in cerebral blood flow, metabolism and EEG signals in the context of AD. You're sure to learn something new! Sections in this episode: Hemodynamics (1:05) Metabolic Changes (9:45) EEG (16:30) ------------------------------------------------------------- PLEASE  FILL OUR SURVEY ...

Anusha will guide you through 21 papers in this episode that target synaptic and neuroprotection as therapeutic intervention for Alzheimer's disease. She covers 3 topics including the use of pre-existing synthetic compounds, naturally occuring compounds, and designing and optimizing drugs to improve efficacy. All of these papers were published in May of 2021 so be sure to check it out to offer your neurons protection from ignorance! Sections in this episode: Using...

In this episode, Naila tackles 21 papers on diet, exercise, complementary therapies, cognitive training, and neurostimulation techniques. There's lots on the potential cellular mechanisms of exercise, several studies using Alzheimer's disease biomarkers as outcome measures, and even a paper on dog-assisted therapy! Hope you enjoy May's smattering of papers on pevention and intervention strategies for AD.   Sections in this episode:Diet (2:52)Exercise (9:01)Multidomain Interventions (26.21)Cognitive training (34:29)Neuromodulatory techniques (37:30) ------------------------------------------------------------- PLEASE  FILL OUR...

Elyn is back with more on all things vasculature! In this episode, she covers 14 papers that span many topics in the field of vascular contributions to Alzheimer disease - all the way from mechanisms linking cardiovascular and metabolic health to the Alzheimer pathology, to clinical studies associating cognitive symptoms with markers of cerebrovascular damage. Tune in to hear a perspective on AD that's outside of the amyloid cascade hypothesis! Sections...

Come join us as Judy covers all topics related to connectivity changes in Alzheimer's Disease. This episode features the latest research on both structural and functional connectivity using methods such as resting-state fMRI, DTI and EEG. Tune in to find out more!   Sections in this episode:  fMRI (2:00)  MRI (10:51)  Other (15:43) ------------------------------------------------------------- PLEASE  FILL OUR SURVEY  TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD....

In this episode, Courtney takes you through the papers from May 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on genetic risk factors, biomarkers associated with ApoE status, risk factors for AD and finally, molecular mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode! Sections in this episode:Genetic Risk Factors (2:12)Biomarkers in Alzheimer's Disease (7:15)Risk Factors...

Ellen kicks off the May 2021 series with 20 papers all about synaptic transmission in Alzheimer's Disease. This includes topics like synaptic plasticity, neurotransmitters like acetylcholine, dopamine, and serotonin and how they're involved in AD, growth factors, morphological changes, and much more! Enjoy the show! Sections in this episode:Neurogenesis (5:11)Synaptic Plasticity (8:46)Neurotransmitter Signaling (18:26)Excitation/Inhibition Balance (28.07)Growth Factors (32:16)Morphological & Anatomical Changes (35:46)-------------------------------------------------------------- PLEASE  FILL OUR SURVEY  TO HELP US IMPROVE OUR PODCAST,...

If you are interested in oxidative stress in Alzheimer’s disease, mitochondrial dysfunction, or metabolism, come hear about the ways they can be targeted for therapeutic purposes. Maybe you are tired of hearing about cholinesterase inhibitors or anti-amyloid-beta antibodies and want to explore something different. Tune in with Sarah in this last episode for our series on the papers published in March 2021. She covers 17 abstracts that harness the interconnectedness...

In this short episode, Joseph goes over 9 studies published in March 2021 that include GWAS’s, ethnicity-specific genetic studies and research on familial AD genetics. Tune in to learn more!  Sections in this episode:  GWAS and other population level studies (2:22)  Ethnicity Specific Studies (7:44)  Familial AD Genetics (11:28)  -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we...

Jacques takes you on a journey through 22 papers on amyloid-beta & aggregation. Ranging from new techniques for amyloid-beta detection, APP-processing, co-pathology & Prion-like mechanisms and some miscellaneous topics pioneering the AD field. Guess you'll just have to stick around until the end! Sections in this episode: Amyloid-beta processing (2:02) Amyloid-beta detection (13:00) Amyloid-beta membrane interactions (18:35) Proteins controlling aggregation, prion protein & prion-like transmission (29:20)  Amyloid-beta & Inflammation (41:17) Miscellaneous (45:35) -------------------------------------------------------------- To access the folder with...

In this episode, you'll hear about the latest research on targeting neuroinflammation, glial cells, autophagy and proteoastis to treat Alzheimer's Disease. This includes some studies that want to increase neuroinflammation and some that want to decrease it! How can they both work? You'll have to listen to find out. Sections in this episode: Treatments targeting Neuroinflammation and Neurodegeneration (3:31) Proteostasis and Autophagy (24:58)  --------------------------------------------------------------You can find the bibliography for this episode by clicking...

In Part 2 of Clinical Markers of AD, Naila will take you through 10 papers on the diagnostic and prognostic value of neuropsychiatric, sensory, motor, or a combination of symptoms. You'll learn about pareidolia, extrapyramidal symptoms, wandering behaviour and more! Sections in this episode: Multiple Symptoms (2:47) Neuropsychiatric Symptoms (6:51) Sensory Symptoms (11:05) Motor Symptoms (18:23) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as...

In part 1 of the clinical markers of AD episodes, Ellen will tell you about papers from March 2021 all about cognition. This includes papers on new cognitive tests, improving or adapting old ones to new situations, learning more about how useful these different assessments really are, AND some really cool papers at the end on new technology and machine learning tools to make AD diagnosis and detection even better!...

Transcriptional and translational dysregulation may cause changes in cellular biology and can lead to disease. In this episode, Marcia brings you the latest research in March 2020 that focus on changes in gene & protein expression and epigenetics in the context of Alzheimer’s disease. Some common terms you’ll hear throughout this episode are transcriptomics, methylome, biomarkers, proteomics, AD models, etc. We also touch upon the up-and-coming field of multiomics, so...

In today's episode, we'll be taking a closer look at papers published in March 2021, studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets.  Topics covered include but are not limited to: butyryrlcholinesterase targeting, PET image processing, and animal models.  Sections in this episode: Amyloid/Tau PET Targets  Tau pathology (1:08)  PET image processing and data analysis (6:45)  Animal models (11:53)  Miscellaneous (14:47)   Other PET...

We've got a tour de force of prevention and intervention papers for you today, covering vascular function, cognitive function, diet, exercise, neuromodulatory techniques and stem cell therapies. Naila will take you throuh 20 papers to update you on the AD literature from March 2021! --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will...

In this episode, Courtney takes you through the papers from March of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, systemic inflammation and so much more! Tune in for this exciting episode!  Sections in this episode: Systemic Inflammation (2.02) Neuroinflammation in Humans (6.27) Astrocytes in AD (9.41) Microglia in AD (13.24) Neuroinflammation in Animal Models (27.38)  --------------------------------------------------------------You...

Tune in as Ellen updates you on all things cognition and behaviour in Alzheimer's disease. Particularly, she'll tell you about new studies from March 2021 that shed light on the characteristics of cognitive and behavioural symptoms in AD, and the underlying neural mechanisms. This episode covers a lot of ground -- memory, executive function, the sense of smell, depression, chewing, and so much more! You're sure to learn a lot...

Tired of the age-old amyloid cascade hypothesis? So is Elyn! Join her in this episode unpacking papers that showed up on PubMed in March 2021 that add more evidence to the tight intertwinement of vascular and brain health. Topics in this episode range from mechanistic studies in animal models looking at cerebral blood flow and blood-brain barrier integrity, all the way to clinical studies mapping out cerebrovascular damage across the...

In this shorter episode, Judy goes through metabolic changes, hemodynamics and functional connectivity papers on Alzheimer's disease, all published in March 2021. Aside from our favorites PET, MRI and EEG, we also look into studies that use less common techniques like SPECT imaging, retinography and MEG. Join us for just 20 minutes of neuroimaging fun! Sections in this episode: PET (1:05) MRI (5:27) EEG (10:24) Other (13:01)  --------------------------------------------------------------To access the folder with all the bibliographies for...

Follow along with Glory in this episode, as we dive into papers that try to uncover the link between changes in synaptic transmission and plasticity with cognitive decline and memory loss in Alzheimer's disease. We'll discuss the most recent research on molecular and structural mechanisms at the synapse that underlie Alzheimer's pathology! Tune in for topics such as presynaptic SNAREs, postsynaptic ion channels, neurotransmitter signalling and more! Sections in this episode: Synapse...

In part 2 of epidemiological studies from March 2021, a particularly loopy, end-of-week Naila will take you through 22 papers on comorbidities and health conditions linked to Alzheimer's disease. We've got some papers on general frailty and comorbidity burden, treatments for other diseases, sleep apnea, cardiovascular risk factors and vision impairment. Sections in this episode:Comorbidities in general  (frailty, dermatitis, cancer, head injury,...) (2.00)Focus on sleep apnea (18.30)Focus on cardiovascular risk  (21.36)Ophthalmic...

In part 1 of epidemiological studies from March 2021, Naila will take you through 12 papers covering prevalence and incidence rates of AD, sociodemographic factors, the potential effects of loneliness, and more. Follow up with Part 2 if you'd like to learn about comorbidities and health risk factors linked to AD! -------------------------------------------------------------- You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021...

Anusha will be summarizing for you papers published in March of 2021 that address neuronal and synaptic health in models of Alzheimer’s disease. That’s not all! We are also going to explore the topic of restoring neurotransmitter balance. So if for instance, you’re looking for research on acetylcholinesterase inhibition, this episode is for you! Sections in this episode: Targeting neuro/synaptic protection with peptides (2.29) Using existing drugs (9.42) Disease mechanisms (17.26) Targeting acetylcholine (21.03) Targeting GABA...

Hooray! The first episode of our March 2021 series is here! In this episode, Courtney takes you through the papers from March 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on ApoE in cognition, ApoE on biomarkers and pathology, and mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode!   Sections in this episode:  Impact of...

Twin studies, GWAS, TWAS, EWAS and more - In this episode, Joseph takes you through 20 papers published in February 2021 that explore novel genes or variants associated with Alzheimer’s Disease, studied associations of novel pathways to AD or link molecular pathways of other diseases to AD.  Sections in this episode:  Comorbidities and other conditions (1:28)  Identification and Validation of Risk Genes and Loci (9:10)  Changes in the Brain (21:02)...

Ellen is bringing you Part 2 of our series on cognitive & clinical indicators to diagnose AD! Make sure to check out episode 143 for Part 1! In Part 2, you'll learn about the latest research validating old & new cognitive tests for AD and mild cognitive impairment, how motor and muscular symptoms can be used to diagnose AD, how body temperature relates to this disease, and the latest in...

In part 1, Naila will take you through 17 papers on characterizing different cognitive profiles of Alzheimer's disease, comparing cognitive measures to pathological biomarkers, optimizing visual and memory tasks, and examining how subjective measures of cognitive decline relate to objective tests. Be sure to check out Part 2 for test validation, motor tasks, and machine learning! Sections in this episode:  Cognitive Profiles & Trajectories (2:10)  Visual Tasks (12:50)  Behaviour, Memory &...

Marcia is back to bring you the latest in Alzheimer's disease treatment development! Join us as we explore the complex relationship between AD and metabolic disorders like diabetes, and some therapies used to co-treat them. Not enough? We also talk about oxidative stress and mitochondrial dysfunction, and (some new!) compounds aimed at mitigating these. Tune in to get your neurons firing! Sections in this episode: 1) Metabolism: 00:58  2) Oxidative stress: 10:15...

Naila provides an overview of February 2021 papers related to preventative factors and non-pharmacological interventions for AD. You'll hear about physical activity, the ketogenic diet, transcranial magnetic stimulation, and dogs! Quite the range in just 20 papers.  Sections in this episode:  Lifestyle/Multiple Factors (1.56)  Physical Activity (5.27)  Diet (14.45)  Social/Emotional Wellbeing (18.50)  Stimulation/Neuromodulatory Techniques (28.38)  -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link...

Deciding what to do during your lunch break or out on a stroll? Well, look no further! Listen in on Abdullah covering the latest papers from February 2021 covering the treatments targeting glia, immune cells, proteostasis and autophagy. Tune in to learn about out of the box ideas that may hold therapeutic benefits for Alzheimer's Disease.   Sections in this episode:  Targeting the Immune System & Glial Cells (3:43)  Targeting Proteostasis...

Judy covers a wide range of neuroimaging modalities in the context of metabolics, hemodynamics and functional connectivity in AD. Tune in if you're a fan of fMRI, PET and EEG, or if you're just looking to learn something new!   Sections in this episode:  fMRI (1:06)  PET (7:28)  EEG (16:29)  fNIRS (20:16)  Other (23:12) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be...

Elyn is back to guide your through all of the connections between blood vessels and Alzheimer disease, from papers published in February 2021. Starting the episode off with how midlife vascular risk factors can influence AD risk, and finishing with treatments for AD that target the vasculature, you're sure to leave this episode appreciating how intertwined heart health and brain health are. Well worth the longer listen for all of...

In this short episode packed full of insight, Jacques navigates the realms of amyloid-beta toxicity in AD. Learn about different techniques and models used to investigate amyloid-beta toxicity, how mouse models can provide insight into toxic amyloid-beta species and the relationship of certain amyloid-beta species with clinical presentations.   Sections in this episode:  Techniques for Investigating Amyloid-beta Toxicity (2:17)  Amyloid-beta Toxicity within Different Cell Types and Species (5:53)  Mouse models of...

Courtney guides you through the latest papers on the immune system and glial cells in the context of Alzheimer's Disease. This includes papers on microglia, astrocytes, and advances in methods to study inflammation in neuroscience. Enjoy!   Sections in this episode:  Microglial Pathway and Receptors (2:44)  Tying Microglia to Astrocytes (19:37)  Astrocytes (22:20)  Models and Methods to Study Inflammation (29:03) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far,...

Follow along with Alex in this episode, as we take a closer look at papers studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets at the end of the episode.  We'll cover topics including deep learning, cerebral amyloid angiopathy, and using the retina as a way of indirectly accessing the brain!   Sections in this episode:  Amyloid and tau-based detection (1:30)  Subsection: Animal models...

A huge focus of Alzheimer's Disease research is understanding the mechanisms behind behavioural symptoms and how to treat them. In this episode, Ellen takes you through papers published in February on topics such as autobiographical memory, sex differences, decision-making, sensory processing, depression, sleep, and so much more!   Sections in this episode:  Cognition (2:43)  Sensory processing (9:07)  Gait disturbances (15:00)  Psychiatric symptoms (18:22)  Sleep (24:31)  --------------------------------------------------------------You can find the bibliography for...

Marcia is back to update you on the latest Alzheimer's research. Today's episode is all about RNA, transcription, translation, proteomics, and more, all in the context of AD. Enjoy.   Sections in this episode:  RNA & Transcription (1:00)  Translation & Proteomics ( 12:28)  Miscellaneous (16:26) --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will...

Want to learn more about how changes in synaptic function, structure and plasticity are implicated in neurodegenerative disease pathology? We've got you covered with this episode! Glory will guide you through 18 papers from February 2021 that explore mechanisms which underlie the synaptic dysfunction that can lead to Alzheimer's disease, ranging from the molecular level to the more global level of brain-wide connectivity.   Sections in this episode:  Synaptic and Axonal...

In this episode, Jacques runs through February 2021's papers on APP processing and amyloid-beta aggregation. Learn about key residues underlying amyloid-beta aggregation, fibrillogenesis-promoting factors and interesting co-pathologies!   Sections in this episode:  APP processing (1:35)  Amyloid beta aggregation (10:50) --------------------------------------------------------------To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1N1zx_itPkCDNYE1yFGZzQxDDR-NiRx3p?usp=sharingYou can...

Curious about ketogenic diets, insomnia and loneliness? Then this episode is just for you! Join Naila as she goes through 23 new epidemiological studies of AD that were published in February 2021, and cover a wide range of potential risk or protective factors of AD. Sections in this episode: Disease prevalence and progression (1:56) Air pollution (4:42) Smoking and Atherosclerosis (9:04) Psychosocial (14:04) Comorbidities and Sleep (22:59) Other Risk Factors (29:41)   --------------------------------------------------------------To access the folder with all...

In this episode, Courtney takes you through the papers from February 2021 on understanding ApoE in Alzheimer's disease and through a few papers on the familial mutations in Alzheimer's disease. There is a wide range of topics so be sure tune in for this exciting episode! Sections in this episode: Cognitive impairment with APOE (2:30) Brain banks to model and predict AD progression (8:56) Mechanisms of APOE (13:11) Familial mutations (17:42)  --------------------------------------------------------------You can find the...

To kick of the February 2021 series, Anusha guides you through papers recently published that target synaptic health and  acetylcholinesterase activity to uncover pathological mechanisms that underlie Alzheimer's disease. If you like thinking about thinking, look no further than this episode!   Sections in this episode:  Synaptic Plasticity and Preservation (2:05)  Oxidative Stress (8:52)  Miscellaneous (12:37)  Acetylcholinesterase Inhibitor Rivastigmine (17:47)  Novel Inhibitors (21:36)   --------------------------------------------------------------You can find the bibliography for this episode...

Welcome to the baptists, the tauists, and all protein aggregation and misfolding enthusiasts from the beautiful realm of neuroscience. This episode is for you if you study amyloid-beta aggregation and toxicity in Alzheimer's disease. You will hear about fibrillar assembly, staining techniques to identify those sneaky aggregates, and strategies to inhibit this process in the hope of developing targeted therapeutics. Come hear condensed summaries of the findings published in January...

In this episode we’ll cover all things metabolism, hemodynamics and connectivity in the brain, in AD. We’ll cover 26 papers published in January 2021, that dive deeper into these research topics, so tune in!   Sections in this episode:  Metabolism (1:42)  Hemodynamic (4:28)  Connectivity changes (11:46)  Miscellaneous (24:56) --------------------------------------------------------------To access the folder with the bibliographies for the month of January, follow this link (it will be updated as we publish episodes and...

Join Naila for 24 papers published in January 2021 on preventive strategies and non-pharmacological interventions for treating AD. She’ll catch you up on the latest exercise interventions, the various diets under investigation for AD prevention, invasive and non-invasive stimulation techniques, cognitive therapy and a few miscellaneous papers.   Sections in this episode:  Exercise and Physical Activity (2.09)  Diet and Obesity (20.46)  Cognitive and Psychological Interventions (34.01)  Stimulation Techniques/Non-Invasive and Invasive Techniques...

Anusha is your guide through 14 papers which target neurotransmitter balance. These papers were all published in January 2021 and focus mostly on targeting acetylcholinesterase activity with a sprinkling of other targets such as NMDA receptors. If you love synapses and are dying to find out how we can get them working properly again in AD, make sure to give this episode a listen!   Sections in this episode:  Targeting Acetylcholinesterase...

In this episode, Maria covers papers from January 2021 exploring cognitive and neuropsychiatric assessments that can be used to evaluate early AD or progression to AD.  The studies look at tests and questionnaires related to learning and memory, functional status, and neuropsychiatric symptoms, including online adaptations of cognitive assessments when in-person visits are not always possible.   Sections in this episode:  Different tests for learning and memory as potential MCI or...

In this episode, Courtney takes you through the papers from 2021 on the role of Immune systems and glial cells in Alzheimer's disease pathology. The papers relate to neuroimaging, astrocytes, microglia, and  broader inflammatory topics and pathways. Be sure to tune in for this exciting episode!   Sections in this episode:  Neuroimaging and Alzheimer's disease (2:01)  Methods of studying inflammation (5:40)  LPS-induced inflammation (7:59)  Astrocytes (11:40)  Microglia Neuropathology (15:27)  Molecular mechanisms...

In this episode, the first of a two-part mini series, Jacques runs through papers from January 2021 on amyloid-beta oligomers in aggregation and therapeutics strategies to target them. Tune in to hear about conformational changes, molecules that affect oligomerisation, oligomer conformation-specific treatment strategies and more!   Sections in this episode:  Oligomerization/Conformation, etc. (2:25)  Strategies targeting oligomers (19:06)   ------------------------------------------------------------------  You can find the bibliography for this episode by clicking this link. To access the...

The rapidly evolving field of Alzheimer’s research is always discovering new genes, variants or even pathways that are associated with this disease. In this episode, Joseph goes over 14 studies from January 2021 that explored novel genes or novel variants, or even studied the associations of novel pathways with AD.   Sections in this episode:  Association studies with gene networks and polygenic risk scores (2:19)  Commonly known genes and pathways (10:14)...

Learn about the studies from January 2021 that used imaging to investigate structural changes in Alzheimer's disease. This includes imaging of different brain regions, as well as other structures like the retina. By better understanding these changes, we can learn more about the disease's pathology and mechanisms, which could lead us to the ability to better treat this disease, or detect it at earlier stages.  Sections in this episode: Deep Learning...

In this episode, Marcia will take you through papers from January 2021 that involve research on targeting mitochondria, metabolism and oxidative stress as effective therapeutic strategies against AD. Tune in to hear about the relation between AD, diet and metabolic diseases like diabetes, the use of nanotechnology and organelle-specific agents to deliver therapy, and more!   Sections in this episode:  Oxidative Stress (1:00)  Metabolism (11:55)  Mitochondria (18:45)  ------------------------------------------------------------------  To access the folder...

Ellen covers papers published this past January on cognitive and neuropsychiatric symptoms in AD and the mechanisms behind them. You'll hear about sensory processing, cognitive and memory deficits, psychiatric symptoms and emotions, and sleep and circadian rhythms in the context of AD. Tune in to learn about the potential mechanisms behind these symptoms, and how they correspond to disease progression.   Sections in this episode:  Sensory Processing (Olfaction, Vision, and Pain)...

 In this episode, Abdullah will cover the latest papers from January 2021 covering development of potential treatments targeting glia, immune cells, proteostasis and autophagy. Tune in to learn about out-of-the-box ideas like how rotten eggs and silver apricots may hold therapeutic benefits for Alzheimer's Disease.   Sections in the episode:  Microglia (3:46)  Astrocytes (7:17)  Glial cells in general (11:43)  Proteostasis & Autophagy (22:49)  ------------------------------------------------------------------  To access the folder with the bibliographies for the...

This longer episode features amyloid and tau detection in the brain, as well as new PET targets of AD! Judy discusses papers from January 2021 that include topics such as AD mouse models, deep learning methods and several different PET tracers. Tune in to find out more!   Sections in this episode:  PET (1:54)  Non-PET (32:51)  New PET Targets (35:22)   ------------------------------------------------------------------  To access the folder with the bibliographies for the month of...

In Part 2 of mechanisms underlying AD risk factors, you'll learn about comorbidities ranging from traumatic brain injury to schizophrenia, hear a little bit about hearing loss, and be exposed to some research on exposure to toxic metals. Naila is your host for today, and will take you through 13 papers from January 2021!   Sections in this episode:  Comorbidities (2.10)  Noise/Hearing Loss (12.02)  Toxic Metal Exposure (16.59)  Neuroprotective Factors (24.49) ------------------------------------------------------------------  Click...

In this episode, Naila covers the first half of peer-reviewed papers publish in January 2021 on mechanisms underlying risk factors of Alzheimer's disease. In 11 papers, she'll go through diabetes, cardiovascular disease and sleep troubles. Enjoy, and check out Part 2 for more!   Sections in this episode:  Diabetes (1:39)  Cardiovascular (5:22)  Sleep (17:15) ------------------------------------------------------------------  Click here to see the list of papers covered in this episode.To access the folder with the bibliographies...

In today’s episode, Marcia brings you the latest research from Jan 2021 on changes to RNA, Transcription and Translation in the context of Alzheimer’s disease. We also talk about some really in-fashion techniques like multi-omics, deconvolution,  mendelian randomization and co-localization. Tune in to learn about these techniques and more!   Sections in this episode:  Multiomics (2 papers) 1:10  Mendelian randomization and colocalization (3) 3:45  Gene pathway and network analysis (2) 7:21...

In this episode, Glory will take you through the papers published on alterations to synaptic transmission and structure in Alzheimer's disease from January 2021. Tune in for all things synaptic - including glutamate receptor signalling, long-term potentiation and dendritic spine integrity! Sections in this episode:  Neurotransmitter signaling: 1.45  Synaptic plasticity: 13.55  Synapse structure: 16.40  Memory: 19.20 ------------------------------------------------------------------  Click here to see the list of papers covered in this episode.To access the folder with...

In this episode, Jacques covers papers from January 2021 on the mechanisms of APP processing in Alzheimer's disease and strategies to alter amyloid-beta production. Learn something new as we explore pathways associated with increased amyloid-beta production, the development of BACE inhibitors and recent clinical trial findings!  ------------------------------------------------------------------  Click here to see the list of papers covered in this episode.To access the folder with the bibliographies for the month of January, follow this...

Elyn is back with more on vascular contributions to Alzheimer disease. Tune in to hear about clinical studies connecting the vasculature to the AD pathology, mechanistic studies about amyloid clearance and deposition into cerebral vessels, and much more - all from papers published in January 2021! Sections in this episode: Clinical Studies - Connecting the Vasculature to the AD Pathology (3.20) Cerebral Amyloid Angopathy (14.36) Cerebral Blood Flow (27.23) Endothelial/Blood-Brain Barrier Damage (30.37)  ------------------------------------------------------------------  Click here...

In this episode on epidemiological studies published in January 2021, Naila will take you through a range of risk factors of AD, including cardiovascular disease, diabetes, other comorbidities, environmental factors, and a few protective factors. There’s a lot of information packed into 21 papers, so you’re sure to feel accomplished after!   Sections in this episode:  Prevalence (1:47)  Comorbidities (4:45)  Comorbidities - Neuro/Psychiatric conditions (20:52)  Environmental Factors (28:10)  Protective Factors (34:16)  Access...

In this episode, Courtney will take you through the papers published on ApoE in Alzheimer's disease from January 2021. The topics covered include the role of ApoE on cognitive function, the impact of ApoE on biomarkers and the molecular mechanisms ApoE impacts.  Be sure to tune in for all things ApoE!!  Sections in this episode:  Cognitive Function (2.00)  Impact of ApoE on Biomarkers (9.43) Molecular Mechanisms (12.43) ------------------------------------------------------------------  Access the list of papers...

In the first episode of our January 2021 series, Anusha will be guiding you through papers that traverse topics within neuroprotection in AD models, including therapies that target A-beta toxicity, glutamate excito-toxicity, and novel therapeutic approaches. We hope you get excited - within reason!   Sections in this episode:  Amyloid-beta toxicity and glutamate excito-toxicity (2:03)  Novel therapeutic strategies (9:30) ------------------------------------------------------------------  Access the list of papers covered in this episode here.To access the...

In this episode, Courtney covers Part 2 of the papers published in September of 2020 on cognitive testing as a diagnostic tool. The topics in this part cover a wide array of topics including brain wave techniques, gait analysis, facial recognition, neuropsychiatric symptoms, and finally cognitive testing.   Sections:  1:56 Brain wave studies in Dementia (2 papers)  4:23 Gait (2 papers)  7:16 Facial Recognition and Facial structure (3 papers)  12:29 Neuropsychiatric...

This shorter episode on metabolic changes and hemodynamics covers a wide range of neuroimaging techniques, including FDG PET, MRI and CT. Judy will discuss the applications of these modalities in deep learning, AD diagnosis and more. Definitely worth a listen if you’re into neuroimaging!   Sections in this episode:  FTG PET papers - 1:02  MRI papers - 9:40 ------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >...

This episode covers recent papers that explore the underlying mechanisms of both protective and risk factors of Alzheimer’s disease. You’ll hear a little about how education, exercise and diet might reduce the risk of cognitive decline later in life, and a lot about the physiological and biochemical factors underlying high fat diets, diabetes, cardiovascular disease and exposure to environmental pollutants - with the occasional  miscellaneous topic in between!   Sections in...

This episode, hosted by Naila, covers papers published in September 2020 that use cognitive testing as a diagnostic tool. These studies vary from validating and comparing existing tests, to refining them for specific applications, to correlating cognition with AD biomarkers. You’ll learn a bit about the variety of cognitive tests used, and how researchers are constantly building on existing tools to better predict the risk and progression of cognitive decline. Sections:Cognition...

In this episode, Marcia will cover papers published in Sept 2020 on treatment development for AD with special focus on the tau protein. She discusses tau in its role as a microtubule-associated protein and the related use of microtubule-stabilizing agents in treating AD. She also talks about papers on immunotherapy, autophagy, and inhibiting tau hyperphosphorylation. Tune in to hear about all of this and more! ------------------------------------------------------------------  To receive the list of...

Can you believe this is our 100th episode??? It has been a little over 6 months since our official launch and we are now running full steam, thanks to a hardworking team. Cheers to the members of AMiNDR, and cheers to you for listening to us. This episode is for those of you who are interested in what’s already on the marker for treating Alzheimer’s diseases. That’s right, you have knowingly...

Alyssa will cover tau protein expression, aggregation, and pathology in Alzheimer’s Disease from studies published in Sept 2020. This episode will dive into papers that examine genetic mutations, toxin exposure and protein interactions that lead to tau pathology and identify potential future therapeutic targets to treat these diseases. A quickie but a goodie if learning more about tau protein is your jam! ------------------------------------------------------------------ To receive the list of papers covered, please fill...

In this episode, Elyn caps off the papers on Cerebrovascular Changes in AD from September 2020. There’s mounting evidence for a significant overlap between vascular disease and brain health, and Elyn dives into the newest papers exploring this relationship. Tune in to hear about how cerebral small vessel disease might be the mediator between arteriosclerosis and cognitive impairment, how APOE is related to microbleeds, and how ACE1 inhibitors might be...

In part 2 of this series, Bhumika continues the deep dive into imaging papers from September 2020 focusing on structural changes and connectivity of the brain, and subsequent white matter changes. Enjoy the episode and tune in to part 1 if you're interested in hearing about more new studies on this topic! ------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting...

In today's episode, Glory updates you on the latest studies from September 2020 on changes to RNA, transcription, and translation mechanisms that may contribute to Alzheimer's disease pathology. Enjoy!   Sections in this episode:  ncRNAs: 1:37  Histone acetylation: 9:55  -Omics: 14:44  Other: 24:52 ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so we can...

In this half-hour episode, Judy goes through September 2020 papers that look at diagnosing or characterizing Alzheimer's disease based on the detection of the proteins amyloid and tau in the brain and other structures. Topics include conventional and novel neuroimaging techniques, deep learning methods and retinal amyloid-beta. Tune in to find out more!   Sections in this episode:   PET  Deep Learning Methods 1:06  Standardized Uptake Value Ratios 4:00  Mild Cognitive Impairment...

Bhumika updates you on the latest papers on brain imaging of structural changes and connectivity in AD! This includes MRI and PET imaging to characterize or diagnosis this disease, as well as new machine learning technology, and more! Enjoy, and look out for part 2 soon! ------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate...

Courtney is back with Part 2 of Inflammation, Glial Cells and TREM2 papers published in September of 2020! If you haven't already, check out Part 1 in episode #91. In this exciting sequel, she discusses methods to study inflammation, astrocytes in inflammation and peripheral immunity. ------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your...

Elyn is back with more on fluid biomarkers for Alzheimer’s Disease from September 2020 papers. Here, she covers new candidate biomarkers including panels of lipids, soluble TREM2, and methylation sites on known risk genes. She also dives into insight into APOE4 mechanisms revealed by biomarkers, the stark overlap between vascular dementia and Alzheimer’s disease, and much more. This is a long one, but definitely worth a listen!   Sections in this...

Courtney updates you on all the new publications from September 2020 about inflammation, glial cells, and TREM2, in the context of Alzheimer's disease. There were a lot of papers on these topics, so we split it up into 2 episodes. Stay tuned for part 2 coming soon! ------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would...

Is the ever-expanding genetic landscape of Alzheimer’s disease overwhelming for you? Joseph will help you catch up on all the literature about new genes or variants linked to Alzheimer’s Disease in September 2020. Sections in this episode:  Novel Gene Discovery - 1:08  New Variant Discovery - 10:24  Testing Associations in Novel Genes - 13:50  Miscellaneous - 18:33 ------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6...

In this episode, Marcia updates you on 8 papers from September 2020 on the development of treatments that target amyloid-beta mediated toxicity to treat Alzheimer's disease. Tune in to hear more! ------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs.  You can fill our feedback...

In today’s episode, you’ll hear about the latest developments in preventing or treating AD using non-pharmacological approaches, such as cognitive interventions, stimulation techniques, and exercise. Naila covers clinical trials in humans and mechanistic studies in animal models, all in 19 papers. Enjoy!  ------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so...

Interested in the behavioural aspects of AD such as changes to cognition, emotion, sleep, sensory and verbal abilities, and learning and memory? Look no further. Anusha will guide you through the literature that was published on these topics in September (2020) to help you start the new year off on the right foot.   Sections in this episode:  1.47 Cognition/Emotional Processing/Depression  10.35 Sleep  17.24 Verbal/Audition/Olfaction  25.04 Learning and Memory ------------------------------------------------------------------  To receive...

Happy New Year from the AMiNDR team! In our first episode of 2021, Abdullah presents on the modulation of inflammatory response in AD, with a big emphasis on microglia, the forgotten heroes in his mind, they clean, repair and protect your brain. Hopefully by the end of the episode you’ll know more about why changing their behaviour could be the treatment we are looking for.   Sections in this episode:  Targeting...

Interested in the mission to accurately diagnose Alzheimer’s disease with a blood test? This episode is perfect for you. In this two-part episode on Fluid Biomarkers in AD from September 2020 papers, Elyn explains the ATN framework for AD diagnosis, and covers papers focused on fluid biomarkers relating to amyloid, tau, and neurodegeneration. She also touches on a few new methods for biomarkers researchers. Tune in to hear about how...

In this episode, Jacques will tell you about new peer-reviewed publications from September 2020 on mechanisms of APP processing and protein aggregation in the context of Alzheimer's disease. This includes aggregation of amyloid-beta as well as other proteins such as tau and alpha-synuclein. Enjoy the episode! ------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate...

In this episode, Marcia covers papers published in September 2020 that focus on the latest in novel drug development in AD. We especially talk about papers targeting amyloid-beta aggregation, BACE-1 inhibitors, gamma-secretase, immunotherapy for AD and more! Tune in to learn more. 5:46 - BACE-1 9:09 - Gamma secretase11:12 - More papers on amyloid-beta aggregation------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting...

Is your research on diet and nutrition and Alzheimer’s disease? Or maybe you are diving deeper into the role of carbs and fat metabolism, and are interested in mitochondrial function in neurodegenerative diseases? Then stay here! Sarah covers 13 papers from our September 2020 harvest with topics ranging from the ketogenic diet to the lipidome.   List of sections:Diet and nutrition: 2.18Carbohydrate and lipid metabolism: 5.44Protective aspects of metabolism: 14.23Mechanisms of...

Elyn is back to cover the latest findings relating to the cerebrovasculature in Alzheimer disease! In this two part episode covering papers from September 2020, you’ll hear about how aging and systemic inflammation can influence the blood-brain barrier, how circulating “good cholesterol” can protect the blood vessels and may be dysfunctional in AD, and a whole lot about cerebral small vessel disease. ------------------------------------------------------------------  To receive the list of papers covered, please...

In this episode, Courtney will update you on papers published in September 2020 on the Disease Mechanisms of ApoE. You will hear about cognitive impacts of ApoE, ethnic variability in ApoE, Neuroimaging of ApoE isoforms, and even some additional genetic implications of ApoE.List of Sections:Impact on Cognitive Abilities:  3.00Ethnic Variability Behind ApoE Isoforms: 14.17Neuroimaging with ApoE Isoforms: 18.20Genetic Mechanisms of ApoE: 24.07------------------------------------------------------------------  To receive the list of papers covered, please...

If you can’t quite decide which episode to listen to, maybe give this one a try. We’re covering preclinical models of AD as it pertains to mitochondria, autophagy, metabolism, behaviour, and much much more. Join Anusha so she doesn’t have to explore all these exciting papers all by herself! List of Sections:Mitochondria:  1.31Autophagy/Metabolism: 5.34Behaviour: 12.12Other: 23.07------------------------------------------------------------------  To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------...

This episode is the second half of a two part series covering papers published in September 2020 on treatment approaches with multiple targets for Alzheimer’s disease. For part 1 of this series, check out episode 74! In this part, we’ll take a look at papers targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation. The final paper in this episode will cover a new study...

You'll hear about how mechanisms of oxidative stress, autophagy and the gut microbiome may contribute to AD pathology, as Abdullah updates you on the new papers from September 2020 on these topics. Enjoy! Sections in this episode: Oxidative stress (6) 2:15Autophagy (2) 13:52Gut microbiome (1) 19:53------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so...

In this episode, Judy goes over papers published in September 2020 that focus on sex differences in Alzheimer’s disease. We also cover a few papers that did not quite fit into our other genetics-themed episodes, including AD-related stigma, lewy body dementia and overlapping risk factors of AD and Parkinson’s disease. Tune in to learn more! Sections in this episode: APOE 1:10 Female-specific AD risks 4:45 CERAD 11:32 Diabetes 15:25 Other 16:38  To learn more about the...

Naila is back to round off the non-genetic risk factors for September, with 6 papers on a variety of potential comorbidities, and 7 more on epidemiological studies and the interaction of various modifiable risk factors. We cover a lot of ground and geographic locations this episode, so buckle in for a solid - but hopefully riveting - half hour of information! ------------------------------------------------------------------ To receive the list of papers covered, please fill this...

In this episode, Alex will be covering papers published in September 2020 within the category of novel drug development, that focus on multi-targeted approaches to Alzheimer’s disease treatment. We’ll take a look at papers targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation. Part 2 will be coming out shortly! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or...

In this episode, Naila goes through 13 papers that explore how benzodiazepine and anticholinergic drug use affect individuals with dementia, whether exposure to certain air pollutants increase the risk of AD, and how cognitive reserve - whether in the form of occupation, bilingualism or education - may protect against cognitive decline. Enjoy!  ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting...

What is it about neurotransmission that is so difficult to regulate in Alzheimer's? Anusha will tell you in this episode, so tune in if you're interested in the role of cholinergic and glutamatergic transmission, or the role of the hippocampus in AD.  ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so we can...

This episode, hosted by Jacques, explores many facets of amyloid-beta mediated toxicity. First, we run through the structure-toxicity relationships of mutant amyloid-beta. Second, we investigate the interaction of amyloid-beta oligomers with membranes and their effect on vesicular trafficking and endocytosis. And lastly, we finish the episode on insights into the effects of amyloid-beta on neurotransmitter systems in AD. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >...

In the first of 3 episodes on AD risk factors for September 2020, Naila covers some of the most studied (arguably) modifiable risk factors, including diet, exercise and sleep. You'll also hear about the effects of hormones and common comorbidities such as diabetes and cardiovascular disease. As many of these factors relate to one another, this will give you a good overview of the literature on common AD risk factors...

Are you invested in the role of neurotransmission in Alzheimer’s disease? Well then buckle in because in this episode, Anusha will go over the latest and greatest compounds that target disease state changes to synaptic transmission in animal and in vitro models of Alzheimer’s.This episode covers the papers published in September of 2020 that use animal models and tissue culture to test the effects of novel compounds for their effects...

Sarah and Elyn are joined by Kyle and Drake from BrainBuzz Podcast to share our journey, growth, and challenges with starting a podcast for science communication in Psychology for them, and Neuroscience for us.  What is it like to talk about our research at cocktail parties? What does starting a podcast require? How does one manage to say "neurodegenerative" without stuttering? This is the second of two crossover episodes. Listen to the...

In this episode, Elyn takes you through a very diverse set of papers on Alzheimer’s disease mechanisms - catching all of the papers that didn’t slot nicely into other episodes. The topics span a wide range from how the reflex of your pupils adjusting to light may be an early indicator of AD, to potentially pathogenic crystals in post-mortem AD brain tissue. There are also several RNA-based papers and signalling...

Today’s episode is on protein expression, aggregation, misfolding and pathology, with an emphasis on tau pathology in Alzheimer’s Disease and we are rounding off the papers published in August 2020. If you are interested in tau spreading in neurodegenerative disease, protein dysfunction in disease and new potential therapeutic targets, Alyssa has got you covered. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by...

Naila is back to round off our risk factors section with an episode on genome-wide association studies, transcriptomic research, combining genetics and neuroimaging data, and new tools to make all this work easier. Tune in to learn more about the techniques used to study the genetic underpinnings of AD, and perhaps to learn some long gene names to impress people at the next party you attend - especially if you...

With over 700km of blood vessels in the brain, it’s no surprise that brain and vascular health are closely related. In this episode, Elyn takes you through papers published in August 2020 on cerebrovascular changes in AD. Tune in to learn more about amyloid clearance, platelet aggregation, and changes in the neurovascular unit over the course of the disease.------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  --------...

Today’s episode is all about Diagnostic Tools and Imaging papers published in August 2020. As you will soon see, these papers explore a wide range of topics including potential biomarkers of AD, hormone markers and EEG analyses. While these papers didn’t quite fit into some of the other diagnostic tools and Imaging subthemes discussed in previous and upcoming episodes (such cognitive testing, imaging tools, fluid biomarkers, and using Amyloid and...

n this episode, Alex will be covering papers published in August 2020 within the category of novel drug development, that focus on multi-targeted approaches to Alzheimer’s disease treatment, and a few papers that don’t quite fit under any of the themes we’ve covered so far. We’ll take a look at studies targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation.------------------------------------------------------------------ To receive the list of papers...

Naila covers a wide variety of biomarkers and topics from papers published in August 2020 on Alzheimer's disease: identifying biomarkers of cognition and memory in cognitively unimpaired older adults, biomarkers that can help predict AD progression and differentiation, new biomarker assays and tools for improved diagnosis, EEG, metabolic profiling... ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We...

In this episode, Marcia talks about papers published in August 2020 within the novel drug development category that focus on targeting tau, the cholinergic system, mitochondria, metabolism and the immune system, as a way to combat Alzheimer's Disease. Check out episode 56 for the first part, where you'll hear more on novel drug development targeting Amyloid-beta production, aggregation, and toxicity.------------------------------------------------------------------ To receive the list of papers covered, please fill this form:...

Judy covers the second half of papers released in August 2020 on amyloid or tau protein detection in the brain. This selection features mouse models, machine learning, mass spectrometry and other cool methods to detect these biomarkers of Alzheimer’s disease. Check episode 39 for the first part.We hope you find this episode useful and accessible.------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or...

Today we have another episode focused on the latest findings in Alzheimer’s disease blood biomarkers research, where Elyn covers abstracts from papers published in August 2020. These papers were clumped together based on the fact that they all focused on measuring something in the blood to either predict or diagnose Alzheimer disease – making them blood biomarkers!In this episode, you’ll hear about a range of analytes that were useful in...

Feeling PERK-y? An eclectic assortment of papers that address Alzheimer’s disease mechanisms in various ways awaits you in this episode. Anusha Kamesh will be guiding your journey through papers released in August of 2020 that concern metabolism, mitochondrial function, oxidative stress, autophagy, and gut microbiome------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback...

Marcia will tell you about papers published in August 2020 within the Novel drug development category that focus on all things Amyloid-beta. She will cover research focussed on targeting Amyloid-beta production, aggregation, and toxicity, as a way to combat AD.------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so we can better cater...

We may not have a disease-modifying agent for Alzheimer’s disease yet, but there are several approved medications that can help slow down the progression of the disease. Can we improve these medications and make them more potent? Are there different ways we can administer them to improve their efficacy? And while we are talking about approved medications, are there any hidden gems on the market that are being used to...

In this episode, Alex covers the latest research involving CSF biomarkers as a critical diagnostic tool in Alzheimer’s Disease identification and treatment. You’ll hear about some of the more typical clinical CSF biomarkers seen in AD, as well as the signature CSF AD biomarker profile, and you’ll also learn about how some of these CSF  biomarkers relate to the different stages of AD progression and severity.  ------------------------------------------------------------------ To receive the list...

In this episode, Courtney will update you on papers published in August 2020 on the genetic landscapes of ApoE. You will hear about models of ApoE, ethnic variability in ApoE, clinical implications of ApoE, and even some molecular mechanisms of ApoE.------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so we can better...

What role does social media play in academia and science communication nowadays? How can we keep our biases from interfering with fair reporting and objective coverage? Do we need to revise our inclusion criteria for the papers we cover? How relevant is the categorization of research by disease when there is so much overlap in underlying mechanisms? And how much responsibility do we hold through our podcast in shaping people’s...

Ellen tells you about the latest papers on cognitive testing for AD and mild cognitive impairment! This includes papers that delve deeper into how cognition is affected in AD and other disorders, and in some cases compare these changes to neurological data. Other papers validate existing cognitive assessment tools, or describe brand new ones, including new analysis algorithms and computer-based testing. Enjoy the episode! ------------------------------------------------------------------ To receive the list of papers covered,...

Listen to Jacques as he recites tongue-twisters and updates you on the latest papers on amyloid-beta aggregation and toxicity in AD from August, 2020! We hope you like the episode, and if you're interested in amyloid pathology in AD, you might want to check out Jacques' last episode as well, episode 47 on APP processing. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or...

The genetic landscape of Alzheimer's disease can be overwhelmingly broad. In this episode, Joseph is back to tell you about peer-reviewed research dealing with epigenetics, non-APOE related genetic pathways and a couple new genetic models that have been published in August 2020. Enjoy! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so we...

Join Anusha as she dives into papers published from August of 2020 that uncovers the effects of potential therapeutics in animal models for Alzheimer's Disease. In the first section, she covers research that targets multiple aspects of Alzheimer's pathology. In the second section, she focuses on research that aims to improve cognition and memory in animal models. ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6...

In this episode, Jacques updates you on the newest papers related to amyloid precursor protein processing in AD! You'll hear about the gamma secretase complex, the influence of accessory proteins on amyloidogenic cleavages of APP, and  APP glycosylation patterns, among other interesting topics! Enjoy.  ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by tweeting at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback...

Bhumika is back to tell you more about the latest tools and techniques in imaging to diagnosis Alzheimer's disease from papers published in August 2020. This includes PET imaging, MRI, and machine learning techniques. If you're interested in this topic, make sure to check out Part 1, which is episode 43, as well. Enjoy! ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  -------- >  https://forms.gle/CVVbznAFM8pamdgk6  -------  or by...

In this episode, Naila takes you through peer-reviewed research published in August 2020, on the many non-pharmacological approaches to treating AD. She covers a lot of territory, from diet-based approaches, to exercise programs and their potential underlying mechanisms, to brain stimulation and some more esoteric treatments. This episode is sure to leave you with some food for thought.  ------------------------------------------------------------------ To receive the list of papers covered, please fill this form:  --------...

You'll hear about some big topics in Alzheimer's disease research in this episode! Ellen covers all of the pre-clinical studies from August 2020 testing potential new treatments targeting neuroinflammation, oxidative stress, mitochondria, metabolism, and lipids. This is the second part of three pre-clinical testing episodes this month, check out episode #42 for part 1, and look out for part 3, coming soon!------------------------------------------------------------------ To receive the list of papers covered, please fill...

Bhumika updates you on the new papers that use brain imaging to diagnose and study AD, in the first of two episodes on this topic! This includes new advances in MRI and PET imaging, and machine learning approaches. You'll hear about studies that looked at changes to functional connectivity, cortical thickness, and other neurological changes in AD, as well as new and improved methods to analyze brain imaging data. Stay...

In Part 1 of the AD preclinical testing papers published in August 2020, Naila gets us started with some treatments that target the cholinergic system and synaptic function, tau phosphorylation and resulting pathology, and amyloid-beta mediated toxicity. Given these are some of the hallmarks of AD pathology, trying to prevent or reverse their effects could lead to promising therapeutic outcomes, which these papers first explore in animal models. Naila will...