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Profile – Dr Alexi Nott, Imperial College London

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12/09/2024

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Dr Alexi Nott

Name:

Dr Alexi Nott

Job Title:

Lecturer and UK DRI Group Leader

Place of work / study:

Imperial College London

Area of Research:

Epigenomics and dementia

How is your research funded:

UK Dementia Research Institute, The Dunhill Medical Trust and Alzheimer’s Association

Tell us a little about yourself:

I am a Lecturer in the Department of Brain Sciences at Imperial College and a Group Leader at the UK Dementia Research Institute. My research centers on the epigenetic mechanisms that contribute to dementia, using advanced epigenetic tools to explore the genetic risks specific to different cell types and uncover the transcriptional drivers behind gene expression changes in neurodegenerative diseases. I also founded the LGBTQ+ Allies Network within Imperial Brain Sciences, aimed at promoting the visibility of scientists within our community.

Tell us a fun fact about yourself:

Hitched hiked from the University of Bath to Paris with one of my dearest friends.

Why did you choose to work in dementia research?

My motivation for research comes from the growing impact of dementia as our population ages, affecting not only patients but also their families and caregivers in profound ways. Despite recent advancements in Alzheimer’s therapeutics, there is still a long way to go in addressing the full scope of the disease. I believe that epigenetics offers a unique perspective on understanding the disease and holds the potential to uncover new biomarkers and therapeutic targets that could make a real difference.

What single piece of advice would you give to an early career researcher?

Surround yourself with mentors at different stages of their careers to gain diverse perspectives. Stay curious and focus on research that truly excites and fulfills you!