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Microglial immunophenotype in the human brain
06/03/2023 @ 4:00 pm - 5:00 pm
European Microglial Webinar Series
Delphine Boche from the University of Southampton, UK
“Genome wide association studies have implicated several inflammation-related genes as risk factors for Alzheimer’s disease, particularly in relation to innate immunity, suggesting a component of microglial activity is likely to be causal in the pathogenic pathway. Therefore, we have developed a number of microglial markers to immunophenotype microglia in the human brain. I will present our findings on microglial immunophenotype obtained on human post-mortem cohorts of Alzheimer’s disease and dementia with Lewy bodies as well as on our unique cohort of brains from Alzheimer’s patients enrolled in the first clinical trial of Aβ42 immunotherapy (AN1792, Elan Pharmaceuticals). These studies highlight the complexity and diversity of microglial responses in dementia and their involvement in therapeutic studies.”
