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Microglia & astrocyte involvement in synapse loss in AD
02/05/2023 @ 4:00 pm - 5:00 pm
The next talk of the European Microglial Webinar Series will be held on Tuesday, May 2nd, starting at 4pm (BST)/5pm (CEST)/6pm (EEST) – please note that the webinar is scheduled for Tuesday rather than Monday, to avoid public holidays in May.
The talk will be given by Professor Tara Spires-Jones from the University of Edinburgh, UK.
Abstract
Synapse loss is the strongest pathological correlate of cognitive decline in Alzheimer’s disease (AD) and genetic data strongly implicate both amyloid beta and changes in microglia in disease pathogenesis. In this talk, Prof Spires-Jones will talk about her work showing that (1) Amyloid beta (Ab) accumulates in synapses and contributes to synapse loss, (2) APOE4 and CLU risk genes associated with synapse loss, (3) Astrocytes and microglia ingest synapses in human AD brain, and (4) Blocking MFGE8 binding integrin receptors reduces human synapse phagocytosis by microglia and astrocytes.
