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Medicine at the Crick

Name: Medicine at the Crick
Start: 2024-11-18T09:30:00+00:00
End: 2024-11-18T17:00:00+00:00
Location: Francis Crick Institute

November 18 @ 9:30 am - 5:00 pm

This 15th edition of Medicine at the Crick will be hosted by Anne Schreiber (The Francis Crick Institute) and Radoslav Enchev (The Francis Crick Institute) on behalf of the AstraZeneca-Crick-Imperial Prosperity Partnership.

Many human diseases are caused by a deregulation of cellular components. Most traditional drugs target disease-causing proteins aiming to inhibit their activity by binding to their active site. However, specificity is often challenging, and only a small subset of these harmful proteins can be targeted in this way. A promising new class of drugs, known as induced proximity therapeutics, addresses these shortcomings by bringing two proteins close together to trigger functional changes or degradation, thereby suppressing the disease-causing effect. This shift from blocking to actively changing a protein of interest by engaging other cellular factors represents a groundbreaking new approach in drug development, expanding into previously undruggable targets to treat many diseases including cancer, inflammation, and neurodegeneration.

Speakers and panellists include: Prof Ray Deshaies (Amgen), Dr Miklos Bekes (Arvinas), Dr Leon Murphy (Casma Therapeutics), Prof Zoran Rankovic (Institute of Cancer Research), Prof Michael Bronstein (University of Oxford), Prof Charlotte Deane (EPSRC and the University of Oxford), Dr Cristina Mayor-Ruiz (IRB Barcelona), Prof Christina Woo (Harvard University), Prof Sagar Lonial (Winship Cancer Institute of Emory University), Prof Ivan Dikic (Goethe University Frankfurt)

Lectures will be followed by a Q&A panel discussion and a networking reception for in-person attendees.

A more detailed programme will be made available soon.

The speaker programme is in-part supported by a UKRI Prosperity Partnership Award involving AZ, the Crick and Imperial College: Developing a rule book for rational discovery of molecular glues for intractable targets.

Programme

09:00 – Registration and breakfast
09:30 – Radoslav Enchev, Welcome and introduction to the AZ-Crick-Imperial Prosperity Partnership
09:45 | Keynote Lecture, Prof Ray Deshaies | Amgen, “The Future of Multispecific Medicines”
10:30 – Dr Miklos Bekes | Arvinas, “PROTAC targeted protein degraders – pioneering an emerging therapeutic modality”
10:55 – Tea & Coffee break
11:25 – Prof Christina Woo | Harvard University, “Rewriting protein modifications”
11:50 – Dr Cristina Mayor-Ruiz | IRB Barcelona, “Chasing molecular glue degraders”
12:15 – Lunch break
13:15 – Dr Leon Murphy | Casma Therapeutics, “Discovery of proximity approaches that unlock the therapeutic potential of autophagy”
13:40 – Prof Ivan Dikic | Goethe University Frankfurt, “Discovery of novel molecular glues & Anti-microbial PROTACs”
14:05 – Prof Charlotte Deane | EPSRC and the University of Oxford, “How far are we from designing an antibody therapeutic on a computer?”
14:30 – Prof Michael Bronstein | University of Oxford, “Harnessing geometric machine learning for molecular design”
14:55 – Tea & Coffee break
15:25 – Prof Zoran Rankovic | Institute of Cancer Research, “Tips and tricks for developing orally bioavailable PROTACs”
15:50 – Prof Sagar Lonial | Winship Cancer Institute of Emory University, “Pillars of Progress in Myeloma”
16:15 – Q&A and Panel Discussion
17:15 – End of symposium followed by networking and drinks reception for in-person attendees