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Blood-Brain Barrier Transport in Aging & Alzheimer’s
24/04/2024 - 25/04/2024
NIA will host the Blood-Brain Barrier Transport in Aging and Alzheimer’s Disease Workshop on April 24th and April 25th, 2024, from 11:00 a.m. to 5:10 p.m. ET.
The blood-brain barrier (BBB) is a selective, semipermeable barrier that controls the transport of substances to and from the central nervous system. It’s composed of endothelial cells (separated by tight junctions), pericytes, the foot processes of astrocytes, and the basement membrane. The BBB poses a significant obstacle to drug development for diseases and conditions of the aging brain, including Alzheimer’s disease.
BBB dysfunction is also a feature of both aging and Alzheimer’s disease, characterized in part by increased BBB permeability to harmful toxins, pathogens, and other molecules and cells that are normally prevented from entering the brain. The Division of Neuroscience within the National Institute on Aging is sponsoring this two-day, virtual workshop on Blood-Brain Barrier Transport in Aging and Alzheimer’s Disease. The purpose of this workshop will be to bring together experts in the field to discuss the following research topics:
- Transport mechanisms in the BBB and how they are altered in aging and Alzheimer’s disease
- Tools and models that enable the study of whether and how transport occurs across the BBB (in vitro, in vivo, and in silico)
- Strategies for enabling drugs to cross the BBB, and their preclinical and clinical applications, including how BBB changes in aging and Alzheimer’s disease may impact drug transport strategies
- The BBB as both an obstacle and target for drug development
- Gaps and opportunities within the field of BBB transport in aging and Alzheimer’s disease
Audience
Researchers interested in learning more about the mechanisms of blood-brain barrier transport, how they’re affected in aging and Alzheimer’s disease, and how they can be utilized to enable drug delivery to the Central Nervous System (CNS).
Dates
April 24, 2024 | 11:00 a.m. – 5:10 p.m. ET
April 25, 2024 | 11:00 a.m. – 5:10 p.m. ET
Location
This workshop will be available for participants to join virtually through Zoom.
Registration
Agenda
Agenda is forthcoming
Contact Information
Please contact Elizabeth Newman for questions you may have about the workshop.
NIA BBB Transport Planning Group Members:
- Elizabeth Newman, Division of Neuroscience, NIA
- Nandini Arunkumar, Division of Neuroscience, NIA
- Marc Charette, NHLBI
- Jue Chen, NHLBI
- Arvind Shukla, NINDS
Reasonable Accommodation: If you need reasonable accommodation to participate in this event, please contact the meeting organizer listed under Contact information. Please make your request no later than 1 week before the event.
