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Enabling dementia research using UK Biobank

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15/07/2023
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Talks from a special webinar hosted by the UK Dementia Research Institute exploring opportunities to harness the UK Biobank’s data resources for your research.

In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility.

Principles of design for UK Biobank and implications for its use - UK DRI Biobank Webinar Prof Naomi Allen (UK Biobank) Speaker bio Naomi Allen is a Professor in Epidemiology, based in the Nuffield Department of Population Health, University of Oxford. She joined UK Biobank as Senior Epidemiologist in 2011, and became Chief Scientist in 2019, where she is responsible for co-ordinating the future scientific strategy of the resource, including following-up participants’ health through linkage to routine health-related datasets and web-based questionnaires. Her research interest is largely in the role of diet, obesity and circulating biomarkers in cancer development. About Biobank webinar This talk was part of a special webinar from the UK Dementia Research Institute exploring opportunities to harness the UK Biobank's data resources for dementia research. In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility. The webinar was chaired by Prof Paul Matthews (Centre Director, UK DRI at Imperial) and Prof Ioanna Tzoulaki (Imperial College London). Links to all the talks from the sessions can be found below: - Prof Naomi Allen (UK Biobank) - Principles of design for UK Biobank and implications for its use - https://youtu.be/URJCDOOwZEs - Dr Eugene Duff (UK DRI at Imperial) - Does SARS-CoV-2 infection trigger neurodegenerative pathology? - https://youtu.be/47npIF9-0Ho - Dr Cynthia Sandor (UK DRI at Cardiff) - Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - https://youtu.be/sBNARp9mmVI - Prof Valentina Escott-Price (UK DRI) - Improving the prediction of Alzheimer’s disease - https://youtu.be/2Svdrt3Uefw - Dr Abbas Deghan (UK DRI at Imperial) - Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - https://youtu.be/suL9qXP5O4o If you enjoyed this session about UK Biobank, catch up on a recent webinar hosted by DNAnexus exploring longitudinal and multimodal data science approaches to dementia & multimorbidity in late-life disease - https://youtu.be/44ZGPnz9GLM To hear about the latest news and events from the UK DRI, sign up to our monthly newsletter: https://tinyurl.com/ukdri-newsletter About UK Biobank UK Biobank is a 500,000-person prospective longitudinal population-based resource harbouring health records, genetic information and a wealth of fluid biomarker and imaging data, as well as measures of physical health, cognitive and sensory functions. It is uniquely rich amongst open, large population data resources for the extent of the subject phenotyping, which includes in depth, research quality multi-organ clinical imaging currently on more than 60,000 participants Currently, participants are ~46-85 years old with 15 years follow-up. The numbers of incident dementias in the cohort are rising rapidly from ~5000 in 2020 to 14,000 expected by 2030. Thus, UK Biobank ‘Big Data’ is a prime resource for dementia research, especially to understand risk factors, early disease stages and progression.

Principles of design for UK Biobank and implications for its use - UK DRI Biobank Webinar
Prof Naomi Allen (UK Biobank)

Speaker bio
Naomi Allen is a Professor in Epidemiology, based in the Nuffield Department of Population Health, University of Oxford. She joined UK Biobank as Senior Epidemiologist in 2011, and became Chief Scientist in 2019, where she is responsible for co-ordinating the future scientific strategy of the resource, including following-up participants’ health through linkage to routine health-related datasets and web-based questionnaires. Her research interest is largely in the role of diet, obesity and circulating biomarkers in cancer development.

About Biobank webinar
This talk was part of a special webinar from the UK Dementia Research Institute exploring opportunities to harness the UK Biobank's data resources for dementia research. In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility.

The webinar was chaired by Prof Paul Matthews (Centre Director, UK DRI at Imperial) and Prof Ioanna Tzoulaki (Imperial College London).

Links to all the talks from the sessions can be found below:
- Prof Naomi Allen (UK Biobank) - Principles of design for UK Biobank and implications for its use - https://youtu.be/URJCDOOwZEs
- Dr Eugene Duff (UK DRI at Imperial) - Does SARS-CoV-2 infection trigger neurodegenerative pathology? - https://youtu.be/47npIF9-0Ho
- Dr Cynthia Sandor (UK DRI at Cardiff) - Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - https://youtu.be/sBNARp9mmVI
- Prof Valentina Escott-Price (UK DRI) - Improving the prediction of Alzheimer’s disease - https://youtu.be/2Svdrt3Uefw
- Dr Abbas Deghan (UK DRI at Imperial) - Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - https://youtu.be/suL9qXP5O4o

If you enjoyed this session about UK Biobank, catch up on a recent webinar hosted by DNAnexus exploring longitudinal and multimodal data science approaches to dementia & multimorbidity in late-life disease - https://youtu.be/44ZGPnz9GLM

To hear about the latest news and events from the UK DRI, sign up to our monthly newsletter: https://tinyurl.com/ukdri-newsletter

About UK Biobank
UK Biobank is a 500,000-person prospective longitudinal population-based resource harbouring health records, genetic information and a wealth of fluid biomarker and imaging data, as well as measures of physical health, cognitive and sensory functions. It is uniquely rich amongst open, large population data resources for the extent of the subject phenotyping, which includes in depth, research quality multi-organ clinical imaging currently on more than 60,000 participants

Currently, participants are ~46-85 years old with 15 years follow-up. The numbers of incident dementias in the cohort are rising rapidly from ~5000 in 2020 to 14,000 expected by 2030. Thus, UK Biobank ‘Big Data’ is a prime resource for dementia research, especially to understand risk factors, early disease stages and progression.

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YouTube Video UExMWE9wZ0xpZFpMNGtYWjlrZHN0LXBaTFN0Q0NMQmxpZi41NkI0NEY2RDEwNTU3Q0M2

Principles of design for UK Biobank and implications for its use - UK DRI Biobank Webinar

UK Dementia Research Institute - UK DRI 14/07/2023 8:51 am

Does SARS-CoV-2 infection trigger neurodegenerative pathology? Dr Eugene Duff (UK DRI at Imperial) Speaker bio Eugene Duff’s research focuses on analytic and computational challenges in resolving spatial and temporal properties of brain structure and function. He has worked extensively in neuroimaging, and at the UK DRI at Imperial College focuses on a variety of single cell and spatial transcriptomic techniques that can reveal genomic signatures of the emergence of dementia. His interests include inference on complex neurobiological datasets, multi-study integration and the development of reproducible analysis pipelines. About Biobank webinar This talk was part of a special webinar from the UK Dementia Research Institute exploring opportunities to harness the UK Biobank's data resources for dementia research. In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility. The webinar was chaired by Prof Paul Matthews (Centre Director, UK DRI at Imperial) and Prof Ioanna Tzoulaki (Imperial College London). Links to all the talks from the sessions can be found below: - Prof Naomi Allen (UK Biobank) - Principles of design for UK Biobank and implications for its use - https://youtu.be/URJCDOOwZEs - Dr Eugene Duff (UK DRI at Imperial) - Does SARS-CoV-2 infection trigger neurodegenerative pathology? - https://youtu.be/47npIF9-0Ho - Dr Cynthia Sandor (UK DRI at Cardiff) - Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - https://youtu.be/sBNARp9mmVI - Prof Valentina Escott-Price (UK DRI) - Improving the prediction of Alzheimer’s disease - https://youtu.be/2Svdrt3Uefw - Dr Abbas Deghan (UK DRI at Imperial) - Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - https://youtu.be/suL9qXP5O4o If you enjoyed this session about UK Biobank, catch up on a recent webinar hosted by DNAnexus exploring longitudinal and multimodal data science approaches to dementia & multimorbidity in late-life disease - https://youtu.be/44ZGPnz9GLM To hear about the latest news and events from the UK DRI, sign up to our monthly newsletter: https://tinyurl.com/ukdri-newsletter About UK Biobank UK Biobank is a 500,000-person prospective longitudinal population-based resource harbouring health records, genetic information and a wealth of fluid biomarker and imaging data, as well as measures of physical health, cognitive and sensory functions. It is uniquely rich amongst open, large population data resources for the extent of the subject phenotyping, which includes in depth, research quality multi-organ clinical imaging currently on more than 60,000 participants Currently, participants are ~46-85 years old with 15 years follow-up. The numbers of incident dementias in the cohort are rising rapidly from ~5000 in 2020 to 14,000 expected by 2030. Thus, UK Biobank ‘Big Data’ is a prime resource for dementia research, especially to understand risk factors, early disease stages and progression.

Does SARS-CoV-2 infection trigger neurodegenerative pathology?
Dr Eugene Duff (UK DRI at Imperial)

Speaker bio
Eugene Duff’s research focuses on analytic and computational challenges in resolving spatial and temporal properties of brain structure and function. He has worked extensively in neuroimaging, and at the UK DRI at Imperial College focuses on a variety of single cell and spatial transcriptomic techniques that can reveal genomic signatures of the emergence of dementia. His interests include inference on complex neurobiological datasets, multi-study integration and the development of reproducible analysis pipelines.

About Biobank webinar
This talk was part of a special webinar from the UK Dementia Research Institute exploring opportunities to harness the UK Biobank's data resources for dementia research. In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility.

The webinar was chaired by Prof Paul Matthews (Centre Director, UK DRI at Imperial) and Prof Ioanna Tzoulaki (Imperial College London).

Links to all the talks from the sessions can be found below:
- Prof Naomi Allen (UK Biobank) - Principles of design for UK Biobank and implications for its use - https://youtu.be/URJCDOOwZEs
- Dr Eugene Duff (UK DRI at Imperial) - Does SARS-CoV-2 infection trigger neurodegenerative pathology? - https://youtu.be/47npIF9-0Ho
- Dr Cynthia Sandor (UK DRI at Cardiff) - Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - https://youtu.be/sBNARp9mmVI
- Prof Valentina Escott-Price (UK DRI) - Improving the prediction of Alzheimer’s disease - https://youtu.be/2Svdrt3Uefw
- Dr Abbas Deghan (UK DRI at Imperial) - Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - https://youtu.be/suL9qXP5O4o

If you enjoyed this session about UK Biobank, catch up on a recent webinar hosted by DNAnexus exploring longitudinal and multimodal data science approaches to dementia & multimorbidity in late-life disease - https://youtu.be/44ZGPnz9GLM

To hear about the latest news and events from the UK DRI, sign up to our monthly newsletter: https://tinyurl.com/ukdri-newsletter

About UK Biobank
UK Biobank is a 500,000-person prospective longitudinal population-based resource harbouring health records, genetic information and a wealth of fluid biomarker and imaging data, as well as measures of physical health, cognitive and sensory functions. It is uniquely rich amongst open, large population data resources for the extent of the subject phenotyping, which includes in depth, research quality multi-organ clinical imaging currently on more than 60,000 participants

Currently, participants are ~46-85 years old with 15 years follow-up. The numbers of incident dementias in the cohort are rising rapidly from ~5000 in 2020 to 14,000 expected by 2030. Thus, UK Biobank ‘Big Data’ is a prime resource for dementia research, especially to understand risk factors, early disease stages and progression.

3 0

YouTube Video UExMWE9wZ0xpZFpMNGtYWjlrZHN0LXBaTFN0Q0NMQmxpZi4yODlGNEE0NkRGMEEzMEQy

Does SARS-CoV-2 infection trigger neurodegenerative pathology? - UK DRI Biobank Webinar

UK Dementia Research Institute - UK DRI 14/07/2023 8:51 am

Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - UK DRI Biobank Webinar Dr Cynthia Sandor (UK DRI at Cardiff) Speaker bio Cynthia Sandor is a Sêr Cymru II Fellow and UK DRI Emerging Leader at the UK DRI at Cardiff, sponsored by Group Leader Prof Caleb Webber. Dr Sandor’s current research is aiming to elucidate the molecular mechanisms underlying disease severity and progression in Parkinson's disease, using a mainly computational strategy. Working with different data types and multiple clinical datasets, her team develop statistical/machine learning approaches to understand and predict the clinical presentation and progression of disease in people living with Parkinson’s. Find out more about Dr Sandor's latest publication on using smart watches to detect Parkinson's here: https://ukdri.ac.uk/news-and-events/smart-watches-could-detect-parkinsons-up-to-seven-years-before-hallmark-symptoms-appear About Biobank webinar This talk was part of a special webinar from the UK Dementia Research Institute exploring opportunities to harness the UK Biobank's data resources for dementia research. In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility. The webinar was chaired by Prof Paul Matthews (Centre Director, UK DRI at Imperial) and Prof Ioanna Tzoulaki (Imperial College London). Links to all the talks from the sessions can be found below: - Prof Naomi Allen (UK Biobank) - Principles of design for UK Biobank and implications for its use - https://youtu.be/URJCDOOwZEs - Dr Eugene Duff (UK DRI at Imperial) - Does SARS-CoV-2 infection trigger neurodegenerative pathology? - https://youtu.be/47npIF9-0Ho - Dr Cynthia Sandor (UK DRI at Cardiff) - Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - https://youtu.be/sBNARp9mmVI - Prof Valentina Escott-Price (UK DRI) - Improving the prediction of Alzheimer’s disease - https://youtu.be/2Svdrt3Uefw - Dr Abbas Deghan (UK DRI at Imperial) - Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - https://youtu.be/suL9qXP5O4o To hear about the latest news and events from the UK DRI, sign up to our monthly newsletter: https://tinyurl.com/ukdri-newsletter If you enjoyed this session about UK Biobank, catch up on a recent webinar hosted by DNAnexus exploring longitudinal and multimodal data science approaches to dementia & multimorbidity in late-life disease - https://youtu.be/44ZGPnz9GLM About UK Biobank UK Biobank is a 500,000-person prospective longitudinal population-based resource harbouring health records, genetic information and a wealth of fluid biomarker and imaging data, as well as measures of physical health, cognitive and sensory functions. It is uniquely rich amongst open, large population data resources for the extent of the subject phenotyping, which includes in depth, research quality multi-organ clinical imaging currently on more than 60,000 participants Currently, participants are ~46-85 years old with 15 years follow-up. The numbers of incident dementias in the cohort are rising rapidly from ~5000 in 2020 to 14,000 expected by 2030. Thus, UK Biobank ‘Big Data’ is a prime resource for dementia research, especially to understand risk factors, early disease stages and progression.

Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - UK DRI Biobank Webinar
Dr Cynthia Sandor (UK DRI at Cardiff)

Speaker bio
Cynthia Sandor is a Sêr Cymru II Fellow and UK DRI Emerging Leader at the UK DRI at Cardiff, sponsored by Group Leader Prof Caleb Webber. Dr Sandor’s current research is aiming to elucidate the molecular mechanisms underlying disease severity and progression in Parkinson's disease, using a mainly computational strategy. Working with different data types and multiple clinical datasets, her team develop statistical/machine learning approaches to understand and predict the clinical presentation and progression of disease in people living with Parkinson’s.

Find out more about Dr Sandor's latest publication on using smart watches to detect Parkinson's here:
https://ukdri.ac.uk/news-and-events/smart-watches-could-detect-parkinsons-up-to-seven-years-before-hallmark-symptoms-appear

About Biobank webinar
This talk was part of a special webinar from the UK Dementia Research Institute exploring opportunities to harness the UK Biobank's data resources for dementia research. In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility.

The webinar was chaired by Prof Paul Matthews (Centre Director, UK DRI at Imperial) and Prof Ioanna Tzoulaki (Imperial College London).

Links to all the talks from the sessions can be found below:
- Prof Naomi Allen (UK Biobank) - Principles of design for UK Biobank and implications for its use - https://youtu.be/URJCDOOwZEs
- Dr Eugene Duff (UK DRI at Imperial) - Does SARS-CoV-2 infection trigger neurodegenerative pathology? - https://youtu.be/47npIF9-0Ho
- Dr Cynthia Sandor (UK DRI at Cardiff) - Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - https://youtu.be/sBNARp9mmVI
- Prof Valentina Escott-Price (UK DRI) - Improving the prediction of Alzheimer’s disease - https://youtu.be/2Svdrt3Uefw
- Dr Abbas Deghan (UK DRI at Imperial) - Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - https://youtu.be/suL9qXP5O4o

To hear about the latest news and events from the UK DRI, sign up to our monthly newsletter: https://tinyurl.com/ukdri-newsletter

If you enjoyed this session about UK Biobank, catch up on a recent webinar hosted by DNAnexus exploring longitudinal and multimodal data science approaches to dementia & multimorbidity in late-life disease - https://youtu.be/44ZGPnz9GLM

About UK Biobank
UK Biobank is a 500,000-person prospective longitudinal population-based resource harbouring health records, genetic information and a wealth of fluid biomarker and imaging data, as well as measures of physical health, cognitive and sensory functions. It is uniquely rich amongst open, large population data resources for the extent of the subject phenotyping, which includes in depth, research quality multi-organ clinical imaging currently on more than 60,000 participants

Currently, participants are ~46-85 years old with 15 years follow-up. The numbers of incident dementias in the cohort are rising rapidly from ~5000 in 2020 to 14,000 expected by 2030. Thus, UK Biobank ‘Big Data’ is a prime resource for dementia research, especially to understand risk factors, early disease stages and progression.

4 0

YouTube Video UExMWE9wZ0xpZFpMNGtYWjlrZHN0LXBaTFN0Q0NMQmxpZi4wOTA3OTZBNzVEMTUzOTMy

Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis

UK Dementia Research Institute - UK DRI 14/07/2023 8:51 am

Improving the prediction of Alzheimer’s disease - UK DRI Biobank Webinar Prof Valentina Escott-Price (UK DRI) Speaker bio Valentina Escott-Price is a Professor in Biostatistics and Bioinformatics at the UK Dementia Research Institute and the division of Neuroscience and mental health at Cardiff University. She uses computational approaches to make sense of increasingly large datasets generated by genetic, clinical and laboratory studies into dementia. She is aiming to identify key drug targets and to redefine how Alzheimer's disease and other dementias are diagnosed in the future. Valentina leads DPUK Work Package 27a in the Experimental Medicine Incubator's Neuroimmunology theme: Polygenic risk and inflammatory pathways. About Biobank webinar This talk was part of a special webinar from the UK Dementia Research Institute exploring opportunities to harness the UK Biobank's data resources for dementia research. In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility. The webinar was chaired by Prof Paul Matthews (Centre Director, UK DRI at Imperial) and Prof Ioanna Tzoulaki (Imperial College London). Links to all the talks from the sessions can be found below: - Prof Naomi Allen (UK Biobank) - Principles of design for UK Biobank and implications for its use - https://youtu.be/URJCDOOwZEs - Dr Eugene Duff (UK DRI at Imperial) - Does SARS-CoV-2 infection trigger neurodegenerative pathology? - https://youtu.be/47npIF9-0Ho - Dr Cynthia Sandor (UK DRI at Cardiff) - Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - https://youtu.be/sBNARp9mmVI - Prof Valentina Escott-Price (UK DRI) - Improving the prediction of Alzheimer’s disease - https://youtu.be/2Svdrt3Uefw - Dr Abbas Deghan (UK DRI at Imperial) - Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - https://youtu.be/suL9qXP5O4o If you enjoyed this session about UK Biobank, catch up on a recent webinar hosted by DNAnexus exploring longitudinal and multimodal data science approaches to dementia & multimorbidity in late-life disease - https://youtu.be/44ZGPnz9GLM To hear about the latest news and events from the UK DRI, sign up to our monthly newsletter: https://tinyurl.com/ukdri-newsletter About UK Biobank UK Biobank is a 500,000-person prospective longitudinal population-based resource harbouring health records, genetic information and a wealth of fluid biomarker and imaging data, as well as measures of physical health, cognitive and sensory functions. It is uniquely rich amongst open, large population data resources for the extent of the subject phenotyping, which includes in depth, research quality multi-organ clinical imaging currently on more than 60,000 participants Currently, participants are ~46-85 years old with 15 years follow-up. The numbers of incident dementias in the cohort are rising rapidly from ~5000 in 2020 to 14,000 expected by 2030. Thus, UK Biobank ‘Big Data’ is a prime resource for dementia research, especially to understand risk factors, early disease stages and progression.

Improving the prediction of Alzheimer’s disease - UK DRI Biobank Webinar
Prof Valentina Escott-Price (UK DRI)

Speaker bio
Valentina Escott-Price is a Professor in Biostatistics and Bioinformatics at the UK Dementia Research Institute and the division of Neuroscience and mental health at Cardiff University. She uses computational approaches to make sense of increasingly large datasets generated by genetic, clinical and laboratory studies into dementia. She is aiming to identify key drug targets and to redefine how Alzheimer's disease and other dementias are diagnosed in the future. Valentina leads DPUK Work Package 27a in the Experimental Medicine Incubator's Neuroimmunology theme: Polygenic risk and inflammatory pathways.

About Biobank webinar
This talk was part of a special webinar from the UK Dementia Research Institute exploring opportunities to harness the UK Biobank's data resources for dementia research. In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility.

The webinar was chaired by Prof Paul Matthews (Centre Director, UK DRI at Imperial) and Prof Ioanna Tzoulaki (Imperial College London).

Links to all the talks from the sessions can be found below:
- Prof Naomi Allen (UK Biobank) - Principles of design for UK Biobank and implications for its use - https://youtu.be/URJCDOOwZEs
- Dr Eugene Duff (UK DRI at Imperial) - Does SARS-CoV-2 infection trigger neurodegenerative pathology? - https://youtu.be/47npIF9-0Ho
- Dr Cynthia Sandor (UK DRI at Cardiff) - Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - https://youtu.be/sBNARp9mmVI
- Prof Valentina Escott-Price (UK DRI) - Improving the prediction of Alzheimer’s disease - https://youtu.be/2Svdrt3Uefw
- Dr Abbas Deghan (UK DRI at Imperial) - Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - https://youtu.be/suL9qXP5O4o

If you enjoyed this session about UK Biobank, catch up on a recent webinar hosted by DNAnexus exploring longitudinal and multimodal data science approaches to dementia & multimorbidity in late-life disease - https://youtu.be/44ZGPnz9GLM

To hear about the latest news and events from the UK DRI, sign up to our monthly newsletter: https://tinyurl.com/ukdri-newsletter

About UK Biobank
UK Biobank is a 500,000-person prospective longitudinal population-based resource harbouring health records, genetic information and a wealth of fluid biomarker and imaging data, as well as measures of physical health, cognitive and sensory functions. It is uniquely rich amongst open, large population data resources for the extent of the subject phenotyping, which includes in depth, research quality multi-organ clinical imaging currently on more than 60,000 participants

Currently, participants are ~46-85 years old with 15 years follow-up. The numbers of incident dementias in the cohort are rising rapidly from ~5000 in 2020 to 14,000 expected by 2030. Thus, UK Biobank ‘Big Data’ is a prime resource for dementia research, especially to understand risk factors, early disease stages and progression.

1 0

YouTube Video UExMWE9wZ0xpZFpMNGtYWjlrZHN0LXBaTFN0Q0NMQmxpZi4wMTcyMDhGQUE4NTIzM0Y5

Improving the prediction of Alzheimer’s disease - UK DRI Biobank Webinar

UK Dementia Research Institute - UK DRI 14/07/2023 8:51 am

Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - UK DRI Biobank Webinar Dr Abbas Deghan (UK DRI at Imperial) Speaker bio Abbas Dehghan MD PhD FESCis a medical doctor and an epidemiologist. In 2016, he joined the Department of Epidemiology and Biostatistics at Imperial College London as a reader in cardiometabolic disorders. Since January 2020, Dr Dehghan is the director of postgraduate research at the school of public health. Dr Dehghan is a member of the steering committee of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and has led or been involved in many genome-wide association (GWAS) studies. Dr Dehghan is working on the genetics of omics, in particular metabolomics, and applying Mendelian Randomisation approach to investigate causal determinants of complex traits and diseases including cardiometabolic disorders, dementia and cancers. About Biobank webinar This talk was part of a special webinar from the UK Dementia Research Institute exploring opportunities to harness the UK Biobank's data resources for dementia research. In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility. The webinar was chaired by Prof Paul Matthews (Centre Director, UK DRI at Imperial) and Prof Ioanna Tzoulaki (Imperial College London). Links to all the talks from the sessions can be found below: - Prof Naomi Allen (UK Biobank) - Principles of design for UK Biobank and implications for its use - https://youtu.be/URJCDOOwZEs - Dr Eugene Duff (UK DRI at Imperial) - Does SARS-CoV-2 infection trigger neurodegenerative pathology? - https://youtu.be/47npIF9-0Ho - Dr Cynthia Sandor (UK DRI at Cardiff) - Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - https://youtu.be/sBNARp9mmVI - Prof Valentina Escott-Price (UK DRI) - Improving the prediction of Alzheimer’s disease - https://youtu.be/2Svdrt3Uefw - Dr Abbas Deghan (UK DRI at Imperial) - Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - https://youtu.be/suL9qXP5O4o If you enjoyed this session about UK Biobank, catch up on a recent webinar hosted by DNAnexus exploring longitudinal and multimodal data science approaches to dementia & multimorbidity in late-life disease - https://youtu.be/44ZGPnz9GLM To hear about the latest news and events from the UK DRI, sign up to our monthly newsletter: https://tinyurl.com/ukdri-newsletter About UK Biobank UK Biobank is a 500,000-person prospective longitudinal population-based resource harbouring health records, genetic information and a wealth of fluid biomarker and imaging data, as well as measures of physical health, cognitive and sensory functions. It is uniquely rich amongst open, large population data resources for the extent of the subject phenotyping, which includes in depth, research quality multi-organ clinical imaging currently on more than 60,000 participants Currently, participants are ~46-85 years old with 15 years follow-up. The numbers of incident dementias in the cohort are rising rapidly from ~5000 in 2020 to 14,000 expected by 2030. Thus, UK Biobank ‘Big Data’ is a prime resource for dementia research, especially to understand risk factors, early disease stages and progression.

Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - UK DRI Biobank Webinar
Dr Abbas Deghan (UK DRI at Imperial)

Speaker bio
Abbas Dehghan MD PhD FESCis a medical doctor and an epidemiologist. In 2016, he joined the Department of Epidemiology and Biostatistics at Imperial College London as a reader in cardiometabolic disorders. Since January 2020, Dr Dehghan is the director of postgraduate research at the school of public health. Dr Dehghan is a member of the steering committee of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and has led or been involved in many genome-wide association (GWAS) studies. Dr Dehghan is working on the genetics of omics, in particular metabolomics, and applying Mendelian Randomisation approach to investigate causal determinants of complex traits and diseases including cardiometabolic disorders, dementia and cancers.

About Biobank webinar
This talk was part of a special webinar from the UK Dementia Research Institute exploring opportunities to harness the UK Biobank's data resources for dementia research. In the session, speakers discussed how the resource was designed, how it can be accessed and exciting ways that it is being developed to increase its future utility.

The webinar was chaired by Prof Paul Matthews (Centre Director, UK DRI at Imperial) and Prof Ioanna Tzoulaki (Imperial College London).

Links to all the talks from the sessions can be found below:
- Prof Naomi Allen (UK Biobank) - Principles of design for UK Biobank and implications for its use - https://youtu.be/URJCDOOwZEs
- Dr Eugene Duff (UK DRI at Imperial) - Does SARS-CoV-2 infection trigger neurodegenerative pathology? - https://youtu.be/47npIF9-0Ho
- Dr Cynthia Sandor (UK DRI at Cardiff) - Wearable devices can identify Parkinson’s disease up to 7 years before clinical diagnosis - https://youtu.be/sBNARp9mmVI
- Prof Valentina Escott-Price (UK DRI) - Improving the prediction of Alzheimer’s disease - https://youtu.be/2Svdrt3Uefw
- Dr Abbas Deghan (UK DRI at Imperial) - Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease - https://youtu.be/suL9qXP5O4o

If you enjoyed this session about UK Biobank, catch up on a recent webinar hosted by DNAnexus exploring longitudinal and multimodal data science approaches to dementia & multimorbidity in late-life disease - https://youtu.be/44ZGPnz9GLM

To hear about the latest news and events from the UK DRI, sign up to our monthly newsletter: https://tinyurl.com/ukdri-newsletter

About UK Biobank
UK Biobank is a 500,000-person prospective longitudinal population-based resource harbouring health records, genetic information and a wealth of fluid biomarker and imaging data, as well as measures of physical health, cognitive and sensory functions. It is uniquely rich amongst open, large population data resources for the extent of the subject phenotyping, which includes in depth, research quality multi-organ clinical imaging currently on more than 60,000 participants

Currently, participants are ~46-85 years old with 15 years follow-up. The numbers of incident dementias in the cohort are rising rapidly from ~5000 in 2020 to 14,000 expected by 2030. Thus, UK Biobank ‘Big Data’ is a prime resource for dementia research, especially to understand risk factors, early disease stages and progression.

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YouTube Video UExMWE9wZ0xpZFpMNGtYWjlrZHN0LXBaTFN0Q0NMQmxpZi41MjE1MkI0OTQ2QzJGNzNG

Discovery of novel causal genes shared between Alzheimer’s disease and cardiovascular disease

UK Dementia Research Institute - UK DRI 14/07/2023 8:51 am

Population-scale datasets offer researchers the ability to derive deeper insights into the genetic mechanisms of late-life diseases like Dementia, but understanding how to tackle analyzing the sheer amount of data remains a challenge. Our panel of research experts review a broad range of multimodal data science approaches that researchers can use to explore the UK Biobank dataset for new discovery. They discuss linking different data types including proteomics, imaging, wearables & genetics and also describe tools powering their analysis and how to access the tools. #dementia #ukbiobank #bioinformatics #genomics #proteomics #imaging #wearables #multimodal #datascience

Population-scale datasets offer researchers the ability to derive deeper insights into the genetic mechanisms of late-life diseases like Dementia, but understanding how to tackle analyzing the sheer amount of data remains a challenge.

Our panel of research experts review a broad range of multimodal data science approaches that researchers can use to explore the UK Biobank dataset for new discovery. They discuss linking different data types including proteomics, imaging, wearables & genetics and also describe tools powering their analysis and how to access the tools.

#dementia #ukbiobank #bioinformatics #genomics #proteomics #imaging #wearables #multimodal #datascience

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YouTube Video UExMWE9wZ0xpZFpMNGtYWjlrZHN0LXBaTFN0Q0NMQmxpZi4xMkVGQjNCMUM1N0RFNEUx

Dementia & Multimorbidity in Late-Life Disease: Longitudinal and Multimodal Data Science Approaches

UK Dementia Research Institute - UK DRI 30/06/2023 3:04 pm

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Find out more about the UK Biobank and how it can support your research – https://www.ukbiobank.ac.uk/

Find out more about the UK Dementia Research Institute – https://ukdri.ac.uk/

Data 58UK Biobank 4UK Dementia Research Institute 117

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UK DRI

The UK DRI breaks new ground by bringing together world-leading expertise in biomedical, care and translational dementia research in a national institute currently made up of over 600 researchers and a support team of over 50, all growing rapidly.

The institute carries out research relevant to all dementias, including Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, vascular dementia, Huntington’s disease and beyond.

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