Biomarkers of Errant Endosome Spotted in Cerebrospinal Fluid
Does jammed-up protein recycling in neurons cause proteins to spill into the cerebrospinal fluid in Alzheimer’s disease? Article from the Alz Forum
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Does Astrocyte Tau Cause Dementia?
Once again, tau creates havoc—this time by hijacking astrocytes. According to a report in Nature from Nicolas Toni at the University of Lausanne
Largest Alzheimer GWAS in African Americans Finds Variants
African Americans have about double the risk of dementia as their non-Hispanic white peers. How much of this is genetics, how much is environment?
Introducing the Coarse-Grained Plaque—A New Type of Amyloid
You’d think that by now we would know all about what amyloid plaques look like? Well, no. Researchers just characterized what they believe to be a distinct type
Can Loss of a Single Protein Cause ‘Alzheimer’s’ in Mice?
Though it carries nary a human transgene, a new mouse model developed many of the hallmark features of Alzheimer’s disease.
Finally: The Alzheimer’s Blood Test We’ve Always Wanted?
Suddenly, phospho-tau217 looks to be the most robust plasma biomarker for Alzheimer’s disease yet. That’s the general consensus…
Could Common Vaccines Protect Against Alzheimer’s?
New reports draw attention to an emerging research trend suggesting that systemic infections could help trigger Alzheimer’s pathology in the brain.
Biogen Asks FDA To Approve Aducanumab
The first new drug for Alzheimer’s disease in more than 16 years in the U.S.? The FDA will be making a judgement within the next six months.
Tau: Why Alzheimer’s Worsens Fast in Some, Slowly in Others
Update on research underlining once more the importance of the soluble tau oligomeric assemblies over long tau filaments in Alzheimer’s disease
Low-Dose BACE Inhibitors Might Preserve Synaptic Function
BACE inhibitors, with their ability to squelch Aβ production, seemed like a promising preventative therapy for Alzheimer’s disease. But could they really work?
Air Pollution & Dementia—Through Hazy Data, Links Emerge
Traffic and industrial exhaust have long been linked to respiratory and cardiovascular disease, but now studies explore link to the brain
Could Tau PET Replace Amyloid Biomarkers for AD?
A large, cross-sectional study finds that RO-948 PET discriminates AD dementia from other disorders more accurately than do CSF biomarkers or MRI