Amyloid Plaques Turn More Toxic as They Age
Combining isotopic labeling and transcriptomics, scientists found that mature plaques in mice wreaked more havoc on surrounding synapses than immature ones.
All posts by Alz Forum
AD Biomarkers Change Similarly Before Symptoms
Explore how two major studies confirm the progression of Alzheimer’s biomarkers, from amyloid to tau, over 20 years leading to diagnosis.
Goodbye, APOE4. Hello, Healthy Brain?
Would carrying a muted version of APOE4, the strongest genetic risk factor of sporadic Alzheimer’s disease, protect against the disorder? Alz Forum explores
Is Alzheimer’s an Autoimmune Disease?
Here’s a tau twist that may take some adapting to. CD4+ and CD8+ T cells, may be responsible for the neurodegeneration seen in Alzheimer’s and other tauopathies
Did Dementia Patient Care Go Downhill During the Pandemic?
New research reports that dementia patients in six countries were more likely to be prescribed antipsychotics during the 2020 lockdowns than before.
Gantenerumab Falls Short in Phase 3
Roche and Genentech announce negative top-line results for their anti-amyloid antibody gantenerumab In the two Phase 3 GRADUATE trials
Forced Into Fat-Burning Mode, Microglia Gobble Up Plaques
Scientists led by Jie Zhang, Xiamen University, reported that hexokinase 2—a pivotal enzyme in glucose metabolism—ramps up in microglia in the AD brain.
A Chat Every Other Day Keeps Dementia at Bay?
Results from the I-CONECT project, led by Hiroko Dodge of Oregon Health and Science University in Portland, sharing benefits of social contact
Behold PANTHOS, a Toxic Wreath of Perinuclear Aβ That Kills Neurons
Mouse models of amyloidosis, poorly acidified lysosomes stuffed with Aβ distort the plasma membranes of neurons and form toxic rosettes around their nuclei.
New CSF & Plama Tests arrive in US
The first FDA approval of a CSF test, and increased options for plasma testing, will give patients easier access to these diagnostic aids.
Drilling Down into the CMS Aduhelm Decision
Medicare limits Aduhelm coverage to clinical trials, but OKs registry-based studies for traditionally approved anti-Aβ antibodies
Benzodiazepines Coax Microglia to Prune Synapses, Impair Cognition
Long-term use of benzodiazepines, commonly prescribed for anxiety, may impair cognition and increase the risk of developing dementia – news from Alz Forum.